Drug Information

Drug (ID: DG01837) and It's Reported Resistant Information

Name	BTI-2571E
Synonyms	3-(4-Methylsulfonylstyryl)-1,2,4-oxadiazole; 24664-14-0; 3-[(E)-2-(4-methylsulfonylphenyl)ethenyl]-1,2,4-oxadiazole; Bti 2571E; Bti 2571(E); SCHEMBL11763943; BTI-2571E; BTI-2571(E); (E)-BTI-2571; 1,2,4-Oxadiazole, 3-(2-(4-(methylsufonyl)phenyl)ethenyl)-, (E)- Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Acute kidney failure [ICD-11: GB60] [1]
Target	.	NOUNIPROTAC	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	3
IsoSMILES	CS(=O)(=O)C1=CC=C(C=C1)/C=C/C2=NOC=N2
InChI	InChI=1S/C11H10N2O3S/c1-17(14,15)10-5-2-9(3-6-10)4-7-11-12-8-16-13-11/h2-8H,1H3/b7-4+
InChIKey	IYACHGURRCRVBZ-QPJJXVBHSA-N
PubChem CID	11970413

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-16: Genitourinary system diseases

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Acute kidney failure [ICD-11: GB60]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Colorectal neoplasia differentially expressed (CRNDE)				[1]
Molecule Alteration	Up-regulation		Expression	Molecule Info
Resistant Disease	Sepsis-induced acute kidney injury [ICD-11: GB60.Z]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
Experiment for Molecule Alteration	Overexpression assay
Experiment for Drug Resistance	Dual luciferase reporter assays; Flow cytometry assay
Mechanism Description	CRNDE overexpression could activate the TLR4/NF-kappa-B signaling pathway by regulating miR-146a, which accelerated LPS-induced inflammation and apoptosis in HK-2 cells.

References

Ref 1	Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney InjuryAnal Cell Pathol (Amst). 2020 May 1;2020:8576234. doi: 10.1155/2020/8576234. eCollection 2020.