Disease Information
General Information of the Disease (ID: DIS00407)
Name |
Acute kidney failure
|
---|---|
ICD |
ICD-11: GB60
|
Resistance Map |
Type(s) of Resistant Mechanism of This Disease
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
BTI-2571E
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Epigenetic Alteration of DNA, RNA or Protein (EADR) | ||||
Key Molecule: Colorectal neoplasia differentially expressed (CRNDE) | [1] | |||
Resistant Disease | Sepsis-induced acute kidney injury [ICD-11: GB60.Z] | |||
Molecule Alteration | Up-regulation | Expression |
||
Resistant Drug | BTI-2571E | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | HK-2 cells | Kidney | Homo sapiens (Human) | CVCL_0302 |
Experiment for Molecule Alteration |
Overexpression assay | |||
Experiment for Drug Resistance |
Dual luciferase reporter assays; Flow cytometry assay | |||
Mechanism Description | CRNDE overexpression could activate the TLR4/NF-kappa-B signaling pathway by regulating miR-146a, which accelerated LPS-induced inflammation and apoptosis in HK-2 cells. |
References
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