General Information of the Disease (ID: DIS00407)
Name
Acute kidney failure
ICD
ICD-11: GB60
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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BTI-2571E
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Colorectal neoplasia differentially expressed (CRNDE) [1]
Resistant Disease Sepsis-induced acute kidney injury [ICD-11: GB60.Z]
Molecule Alteration Up-regulation
Expression
Resistant Drug BTI-2571E
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HK-2 cells Kidney Homo sapiens (Human) CVCL_0302
Experiment for
Molecule Alteration
Overexpression assay
Experiment for
Drug Resistance
Dual luciferase reporter assays; Flow cytometry assay
Mechanism Description CRNDE overexpression could activate the TLR4/NF-kappa-B signaling pathway by regulating miR-146a, which accelerated LPS-induced inflammation and apoptosis in HK-2 cells.
References
Ref 1 Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney InjuryAnal Cell Pathol (Amst). 2020 May 1;2020:8576234. doi: 10.1155/2020/8576234. eCollection 2020.

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