Drug Information

Drug (ID: DG01809) and It's Reported Resistant Information

Name	Succinate
Synonyms	Succinate; Butanedioate; Succinate dianion; Butanedioic acid, ion(2-); 56-14-4; UNII-AJ326AG789; AJ326AG789; succ; monosuccinate; Butanedioate(2-); Succinate ion; succinate(2-); Succinate ion(2-); suc; Succinic acid, ion(2-); DTXSID4036772; CHEBI:30031; ANION STANDARD - SUCCINATE; STL302037; (-)OOC-CH2-CH2-COO(-); AKOS022140212; A802155; Q27104100 Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Oral squamous cell carcinoma [ICD-11: 2B6E] [1]
Target	.	NOUNIPROTAC	[1]
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Formula	1
IsoSMILES	C(CC(=O)[O-])C(=O)[O-]
InChI	InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2
InChIKey	KDYFGRWQOYBRFD-UHFFFAOYSA-L
PubChem CID	160419
INTEDE ID	DR01246

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Oral squamous cell carcinoma [ICD-11: 2B6E]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Maternally expressed 3 (MEG3)				[1]
Molecule Alteration	.		Expression	Molecule Info
Resistant Disease	Oral squamous cell carcinoma [ICD-11: 2B6E.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	CAL-27 cells	Tongue	Homo sapiens (Human)	CVCL_1107
	OLP type I keratinocytes	N.A.	.	N.A.
Experiment for Drug Resistance	Cell Titer-Glo assay; IC50 assay
Mechanism Description	The critical roles of succinate and MEG3 in the metabolic changes during malignant transformation from OLP to OSCC.

References

Ref 1	LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathwayJ Cell Biochem. 2019 Oct;120(10):18172-18185. doi: 10.1002/jcb.29123. Epub 2019 May 29.