Drug Information

Drug (ID: DG01794) and It's Reported Resistant Information

• Name: Hexane-1,6-diol
• Synonyms: 1,6-HEXANEDIOL; Hexane-1,6-diol; 629-11-8; Hexamethylene glycol; 1,6-Dihydroxyhexane; Hexamethylenediol; alpha,omega-Hexanediol; .alpha.,.omega.-Hexanediol; UNII-ZIA319275I; 6-hydroxy-1-hexanol; 1,6-Hexanediol, homopolymer; CHEBI:43078; ZIA319275I; 27236-13-1; HEZ; CCRIS 8982; 1,6-Hexylene Glycol; HSDB 6488; NSC 508; 1,6-Hexanediol solution; EINECS 211-074-0; BRN 1633461; AI3-03307; 1,6hexanediol; 1,6 hexanediol; 1.6-hexanediol; 1,6-hexandiol; 1.6-hexandiol; .omega.-Hexanediol; 1,6-hexane diol; 1,6-hexan-diol; hexan-1,6-diol; Hexanediol-(1,6); DSSTox_CID_7265; 1,6-Hexanediol, 97%; 1,6-Hexanediol, 99%; EC 211-074-0; WLN: Q6Q; DSSTox_RID_78376; HO(CH2)6OH; DSSTox_GSID_27265; SCHEMBL15343; CHEMBL458616; NSC508; DTXSID1027265; NSC-508; ZINC1555566; Tox21_200450; MFCD00002985; AKOS003242194; CS-W011221; DB02210; MCULE-8817570517; NCGC00248624-01; NCGC00258004-01; AS-12686; BP-21412; CAS-629-11-8; DB-027344; FT-0607014; H0099; 1,6-Hexanediol solution, BioUltra, ~6 M in H2O; 1,6-Hexanediol, >=99% C6-Dioles basis (GC); A834086; Q161563; J-504039; F0001-1701
• Indication:
  In total 1 Indication(s)
  Discovery agent [ICD-11: N.A.]; Investigative; [1]
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Fungal infection [ICD-11: 1F29-1F2F]; [1]
• Target: Glucocorticoid receptor (NR3C1); GCR_HUMAN; [1]
• Target: Phospholipase A2 (PLA2G1B); PA21B_HUMAN; [1]
• Formula: 5
• IsoSMILES: C(CCCO)CCO
• InChI: InChI=1S/C6H14O2/c7-5-3-1-2-4-6-8/h7-8H,1-6H2
• InChIKey: XXMIOPMDWAUFGU-UHFFFAOYSA-N
• PubChem CID: 12374
• ChEBI ID: CHEBI:43078
• TTD Drug ID: D0O0ZU

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Fungal infection [ICD-11: 1F29-1F2F]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Sme2 (sme2) [1]

• Molecule Alteration: .; Expression
• Resistant Disease: Fungal infection [ICD-11: 1F29-1F2F]
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: ChIP assay; FISH assay
• Mechanism Description: LncRNA-protein complexes assembled at specific chromosomal loci mediate recognition and subsequent pairing of homologous chromosomes.

Key Molecule: Omt3 (omt3) [1]

• Molecule Alteration: .; Expression
• Resistant Disease: Fungal infection [ICD-11: 1F29-1F2F]
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: ChIP assay; FISH assay
• Mechanism Description: LncRNA-protein complexes assembled at specific chromosomal loci mediate recognition and subsequent pairing of homologous chromosomes.

Key Molecule: Long non-protein coding RNA (LncRNA584) [1]

• Molecule Alteration: .; Expression
• Resistant Disease: Fungal infection [ICD-11: 1F29-1F2F]
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: ChIP assay; FISH assay
• Mechanism Description: LncRNA-protein complexes assembled at specific chromosomal loci mediate recognition and subsequent pairing of homologous chromosomes.

References

• Ref 1: Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombeNat Commun. 2019 Dec 6;10(1):5598. doi: 10.1038/s41467-019-13609-0.