Drug Information

Drug (ID: DG01782) and It's Reported Resistant Information

• Name: Ketamine
• Synonyms: Ketamine; dl-Ketamine; Ketaject; Ketalar; CI 581 base; Special K; (+-)-Ketamine; Ketaminum; CLSTA 20; 6740-88-1; Ketanest; Ketalar base; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; (+/-)-Ketamine; KETAMINE HCL; 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone; Ketolar; 2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone; NSC 70151; 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one; CHEMBL742; CHEBI:6121; Calypsol; 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone; Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-; NSC-70151; 100477-72-3; DEA No. 7285; NCGC00159480-02; NCGC00159480-03; Cetamina; Ketamine Base; Ketamine [INN:BAN]; DSSTox_CID_3187; Ketaminum [INN-Latin]; Cetamina [INN-Spanish]; DSSTox_RID_76912; Special K [street name]; DSSTox_GSID_23187; narketan; Ketoject; Tekam; (+)-Ketamine; Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)- (9CI); Ketamine (INN); PMI-150; CAS-6740-88-1; Tekam (TN); EINECS 229-804-1; (+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone; BRN 2216965; ketamina; Ursotamin; Vetaket; Anaket v; HSDB 2180; Clorketam 1000; Ketasol 100; Imalgene 1000; Ketolar (Salt/Mix); Vetalar (Salt/Mix); Kalipsol (Salt/Mix); Ketanest (Salt/Mix); Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+-)-; (.+/-.)-Ketamine; EC 229-804-1; Cyclohexanone, (.+-.)-; SCHEMBL16103; MLS001331674; DivK1c_000217; cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-; GTPL4233; (+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; DTXSID8023187; SCHEMBL17084881; KBio1_000217; NINDS_000217; HMS2272G05; NSC70151; Tox21_111703; Tox21_111704; BDBM50044140; DB01221; MCULE-4905246871; IDI1_000217; SMR000238141; C07525; D08098; Q243547; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone #; J-505587; (.+/-.)-2-(O-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone(Ketamine); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)- (9CI); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+/-)-; Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (.+/-.)-; Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (.+/-.)-; Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)- (8CI)
• Indication:
  In total 1 Indication(s)
  Anaesthesia [ICD-11: 8E22]; Approved; [1]
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Radiculopathy [ICD-11: 8B93]; [1]
• Target: N-methyl-D-aspartate receptor (NMDAR); NOUNIPROTAC; [1]
• Formula: 2
• IsoSMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl
• InChI: InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
• InChIKey: YQEZLKZALYSWHR-UHFFFAOYSA-N
• PubChem CID: 3821
• ChEBI ID: CHEBI:6121
• TTD Drug ID: D0UM7O
• VARIDT ID: DR0903
• INTEDE ID: DR00685
• DrugBank ID: DB01221

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-08: Nervous system diseases

Radiculopathy [ICD-11: 8B93]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: BLACAT1 overlapping LEMD1 locus (BLACAT1) [1]

• Molecule Alteration: Up-regulation; Expression
• Resistant Disease: Anesthesia-induced neural cytotoxicity [ICD-11: 8B93.Y]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: hiPSCs; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Click-iT TUNEL alexaFluor-594 Imaging assay; Total Reactive Oxygen Species Assay; Caspase-Glo 3/7 assay
• Mechanism Description: Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neurons.

References

• Ref 1: Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neuronsEur J Pharmacol. 2019 Dec 15;865:172737. doi: 10.1016/j.ejphar.2019.172737. Epub 2019 Oct 14.