Disease Information
General Information of the Disease (ID: DIS00418)
Name |
Radiculopathy
|
---|---|
ICD |
ICD-11: 8B93
|
Resistance Map |
Type(s) of Resistant Mechanism of This Disease
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Ketamine
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Epigenetic Alteration of DNA, RNA or Protein (EADR) | ||||
Key Molecule: BLACAT1 overlapping LEMD1 locus (BLACAT1) | [1] | |||
Resistant Disease | Anesthesia-induced neural cytotoxicity [ICD-11: 8B93.Y] | |||
Molecule Alteration | Up-regulation | Expression |
||
Resistant Drug | Ketamine | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | hiPSCs | N.A. | Homo sapiens (Human) | N.A. |
Experiment for Molecule Alteration |
qRT-PCR | |||
Experiment for Drug Resistance |
Click-iT TUNEL alexaFluor-594 Imaging assay; Total Reactive Oxygen Species Assay; Caspase-Glo 3/7 assay | |||
Mechanism Description | Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neurons. |
References
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