General Information of the Disease (ID: DIS00418)
Name
Radiculopathy
ICD
ICD-11: 8B93
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Ketamine
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: BLACAT1 overlapping LEMD1 locus (BLACAT1) [1]
Resistant Disease Anesthesia-induced neural cytotoxicity [ICD-11: 8B93.Y]
Molecule Alteration Up-regulation
Expression
Resistant Drug Ketamine
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model hiPSCs N.A. Homo sapiens (Human) N.A.
Experiment for
Molecule Alteration
qRT-PCR
Experiment for
Drug Resistance
Click-iT TUNEL alexaFluor-594 Imaging assay; Total Reactive Oxygen Species Assay; Caspase-Glo 3/7 assay
Mechanism Description Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neurons.
References
Ref 1 Inhibition of long noncoding RNA BLACAT1 protects anesthesia-induced neural cytotoxicity in human induced pluripotent stem cells derived neuronsEur J Pharmacol. 2019 Dec 15;865:172737. doi: 10.1016/j.ejphar.2019.172737. Epub 2019 Oct 14.

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