Drug Information

Drug (ID: DG01777) and It's Reported Resistant Information

• Name: Oxygen
• Synonyms: 7782-44-7; O; Oxygen; Molecular oxygen; oxygen molecule; Dioxygen; Pure oxygen; Oxygenium; Liquid oxygen; Hyperoxia; Sauerstoff; Oxygen-16; Oxygen (liquid); Oxygen, liquified; Oxygenium medicinale; oxygene; CCRIS 1228; HSDB 5054; O2; UN1072; UN1073; UNII-S88TT14065; Peroxide Ion; CHEBI:15379; S88TT14065; LOX; E948; E-948; Oxygene [French]; Oxigeno [Spanish]; OXY; Compressed oxygen; Oxygen [USP]; EINECS 231-956-9; dioxidanediyl; dioxygene; Disauerstoff; oxygen monoxide; Peroxy radical; singlet dioxygen; triplet dioxygen; Oxygen USP; Oxygen, compressed; Oxygen 93 percent; singlet molecular oxygen; triplet molecular oxygen; Oxygen (8CI,9CI); Oxygen (JP17/USP); dioxygen(2.) (triplet); Oxygen, >=99.6%; Oxygen, compressed [UN1072] [Nonflammable gas]; RNS60 COMPONENT OXYGEN; [OO]; INS NO.948; Oxygen, >=99.998%; CHEMBL1234886; DTXSID2037681; RNS-60 COMPONENT OXYGEN; CHEBI:26689; CHEBI:27140; INS-948; Oxygen, refrigerated liquid (cryogenic liquid) [UN1073] [Nonflammable gas]; DB09140; UN 1072; UN 1073; Oxygen, Messer(R) CANGas, 99.999%; DS-014940; (1)O2; E 948; C00007; D00003; O2(2.); Oxygen, refrigerated liquid (cryogenic liquid); Oxygen, compressed [UN1072] [Nonflammable gas]; (O2)(..); (O2)(2.); Q5203615; UNII-K21NZZ5Y0B component MYMOFIZGZYHOMD-UHFFFAOYSA-N; AQUANAL(TM)-plus oxygen (O2) 1-12 mg/L, refill pack for 37428; AQUANAL(TM)-plus oxygen (O2) 1-12 mg/L, test set with color comparator; 4-Chloro-3-(chloro-difluoro-methyl)-4,4-difluoro-1-thiophen-2-yl-but-2-en-2-one; Oxygen, refrigerated liquid (cryogenic liquid) [UN1073] [Nonflammable gas]
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (1 diseases)
  Lung damage [ICD-11: RA00]; [1]
• Target: .; NOUNIPROTAC; [1]
• IsoSMILES: O=O
• InChI: InChI=1S/O2/c1-2
• InChIKey: MYMOFIZGZYHOMD-UHFFFAOYSA-N
• PubChem CID: 977

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-25: Uncertain aetiology/emergency use

Lung damage [ICD-11: RA00]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Maternally expressed 3 (MEG3) [1]

• Molecule Alteration: Down-regulation; Interaction
• Resistant Disease: Lung damage [ICD-11: RA00]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MLE-12 cells; Lung; Mus musculus (Mouse); CVCL_3751
• In Vivo Model: MEG3 knockdown mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; qRT-PCR; Western bloting analysis; Luciferase assay; ELISA assay
• Experiment for Drug Resistance: MTT assay; LDH assay; Flow cytometry assay; HE staining assay
• Mechanism Description: Knockdown of MEG3 inhibits pyroptosis to alleviate hyperoxia lung injury by suppressing NLRP3 inflammasome and caspase-1 signaling via regulating miR-18a-TXNIP axis.

References

• Ref 1: LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathwayJ Cell Biochem. 2019 Oct;120(10):18172-18185. doi: 10.1002/jcb.29123. Epub 2019 May 29.