Drug Information

Drug (ID: DG01771) and It's Reported Resistant Information

• Name: Ethanol
• Synonyms: Ethanol; ethyl alcohol; alcohol; 64-17-5; grain alcohol; Methylcarbinol; Ethyl hydroxide; Ethyl hydrate; Tecsol; EtOH; Algrain; Anhydrol; Denatured alcohol; Hydroxyethane; Alkohol; Jaysol S; Potato alcohol; Cologne Spirit; Absolute ethanol; Ethanol 200 proof; Molasses alcohol; Spirits of wine; etanol; Aethylalkohol; Denatured ethanol; Aethanol; Alcool ethylique; 1-Hydroxyethane; Fermentation alcohol; Alcohol, diluted; Tecsol C; Alcohols; Alcool etilico; Dehydrated ethanol; Etanolo; Jaysol; Etylowy alkohol; absolute alcohol; Ethanol solution; Alcohol, ethyl; Alcohol dehydrated; Alkoholu etylowego; Ethyl alcohol usp; Alcohol, anhydrous; Synasol; Ethyl alcohol anhydrous; Denatured alcohol CD-5; Denatured alcohol SD-1; Distilled spirits; Denatured alcohol CD-5a; Denatured alcohol SD-3a; Dehydrated alcohol; Denatured alcohol CD-10; Denatured alcohol SD-17; Denatured alcohol SD-28; Denatured alcohol SD-30; Denatured alcohol SD-13a; Denatured alcohol SD-23a; Denatured alcohol SD-39b; Denatured alcohol SD-39c; Denatured alcohol SD-40m; Ethylalcohol; Spirit; SD Alchol 23-hydrogen; Alcohol anhydrous; Alkohol [German]; Aethanol [German]; Etanolo [Italian]; Alcohol, dehydrated; Ethyl alcohol & water, 5%; Thanol; Ethanol, undenatured; Spirt; Alcare Hand Degermer; Ethyl alcohol & water, 10%; Ethyl alcohol & water, 20%; Ethyl alcohol & water, 30%; Ethyl alcohol & water, 40%; Ethyl alcohol & water, 50%; Ethyl alcohol & water, 60%; Ethyl alcohol & water, 70%; Ethyl alcohol & water, 80%; Ethyl alcohol & water, 95%; Ethyl alcohol & water, 96%; Ethyl alc; Ethylalcohol [Dutch]; Ethyl alcohol and water; NCI-C03134; Alcohol (ethyl alcohol); Alcohol [USP]; Ethicap; Hinetoless; Cologne spirits; Caswell No. 430; Reagent Alcohol; Infinity Pure; Aethylalkohol [German]; Desinfektol EL; Anhydrous alcohol; Ethyl alcohol in alcoholic beverages; FEMA No. 2419; FEMA Number 2419; Alcool etilico [Italian]; Etylowy alkohol [Polish]; Ethyl alcohol, undenatured; Alcool ethylique [French]; C2H5OH; Alkoholu etylowego [Polish]; HSDB 82; SDM No. 37; AI3-01706; CCRIS 945; Ethanol Vapor; SD alcohol 23-hydrogen; Alcohol denatured; Ru-Tuss Hydrocodone Liquid; Alcohol, denatured; Ethanol, denatured; Ethanol, Anhydrous; NSC 85228; Alcohol (USP); EPA Pesticide Chemical Code 001501; Absolute ethyl alcohol; UNII-3K9958V90M; Punctilious ethyl alcohol; Ethanol Absolute; Ethanol, anhydrous, denatured; CHEBI:16236; NSC-85228; 3K9958V90M; Ethanol, CDA 19; Ethanol, 200 Proof; Ethyl Alcohol Denatured; Ethylol; Alcohols, C1-3; Ethanol Anhydrous; Alcohol, Absolute; EOH; Ethanol [JAN]; Sekundasprit; alcohol etilico; spiritus vini; MFCD00003568; Anhydrous ethanol; Ethanol denatured; C2H6O; Lux; SY Fresh M; Esumiru WK 88; Ethanol (9CI); Ethanol, silent spirit; ALCOHOL DENAT.; Anhydrol PM 4085; Ethyl alcohol, anhydrous; Ethyl alcohol (Ethanol); Higher alcohol distillate; ALCOHOL 5% IN DEXTROSE 5%; EINECS 200-578-6; Cologne spirits (alcohol); SDA 3A; Alcoholum; Ethanolum; Ethylicum; silent spirit; diluted Alcohol; Ethanol in alcoholic beverages; Vodka; Alcohol,ethyl; Edible alcohol; Alcohol,sda; ethanol-; 100C.NPA; CDA 19; IMS 99; Sd alcohol; Ethanol, dimer; Alcohol,denatured; Alcohol (ethyl); Alcohol,dehydrated; undenatured Ethanol; AHD 2000; Ethanol, dehydrated; SDA 40-2; VANILLA Powder; EINECS 270-649-4; Eosin Y, Alcoholic; Alcohol 95%; Alcohol 190 proof; CDA 19-200; Ethyl Alcohol 40%; Ethyl Alcohol 70%; Ethyl Alcohol 75%; Ethyl Alcohol 80%; Ethyl Alcohol 90%; Ethyl alcohol, absolute; Ethanol, 99.8%; Ethanol, technical grade; Fatty Alcohol C8-10; Reagent Alcohol, 70%; Reagent Alcohol, 80%; Reagent Alcohol, 95%; CH3CH2OH; Dehydrated ethanol (TN); Ethyl Alcohol 47.5%; DSSTox_CID_584; Ethyl alcohol, dehydrated; Ethanol, standard for GC; Industrial Alcohol (IMS); bmse000297; CHEMBL545; EC 200-578-6; Ethanol, >=99.5%; Aerosol OT Solution; Anhydrous ethanol (JP17); Reagent Alcohol, for HPLC; Ethanol, analytical standard; DSSTox_RID_75674; SD 3A; DSSTox_GSID_20584; Ru-Tuss Liquid (Salt/Mix); Ethanol, USP, 99.5%; WLN: Q2; 68475-56-9; Ethanol, for residue analysis; Reagent Alcohol, ACS reagent; Alcohol determination--alcohol; Duplicating Fluid 100C.NPA; Ethanol, p.a., 99.8%; Reagent Alcohol, reagent grade; SDM No. 37 (Salt/Mix); GTPL2299; Alcohol dehydrated, >=85.0%; DTXSID4028331; DTXSID9020584; Ethanol, technical grade, 93%; Ethanol, technical grade, 99%; UNII-7528N5H79B; CHEBI:17246; Ethanol, 95.1-96.9%; poly(vinyl alcohol) macromolecule; Ru-Tuss Expectorant (Salt/Mix); Ethyl alcohol (6CI,7CI,8CI); Ethanol, technical grade, 93.8%; Ethanol, technical grade, 99.5%; Ethanol, >=99.5%, for HPLC; NSC85228; STR05604; Ethyl Alcohol 95% ACS/USP Grade; Tox21_202510; 6869AF; STL264245; Ethanol 2000 microg/mL in Methanol; Ethanol, 95.0%, (190 proof); Ethanol, p.a., ACS reagent, 96%; Ethanol, tested according to Ph.Eur.; Ethanol, USP, 70.0-72.0%; Ethanol, USP, 94.9-96.0%; AKOS009104571; Ethanol, Reagent (Denatured SDA 3A); 7528N5H79B; DB00898; Ethanol 10000 microg/mL in Methanol; Ethanol, absolute, >=99.8% (GC); Ethanol, UV HPLC spectroscopic, 95%; MCULE-8818474596; UN 1170; CAS-64-17-5; Ethanol, denatured, (UK IDA standard); Ethanol, SAJ first grade, >=99.5%; Ethyl Alcohol Absolute, ACS/USP Grade; Ethanol, JIS special grade, >=99.5%; Ethanol, p.a., ACS reagent, 95.0%; Ethanol, technical grade, 92.6-93.8; NCGC00091458-01; NCGC00091458-02; NCGC00260059-01; Reagent Alcohol, spectrophotometric grade; Ethanol, >50% in a non hazardous diluent; Ethanol, absolute, for HPLC, >=99.8%; Ethanol, anhydrous, denatured, HPLC Grade; Ethyl Alcohol 95% (Synthetic) FCC Grade; Ethanol, ACS reagent, 99.8, 200 proof; Ethanol, JIS first grade, 94.8-95.8%; Ethyl Alcohol Absolute (Organic) USP Grade; E1510; Ethanol solution, EP, BP, 69.5-70.4%; Ethanol, denatured, Spectrophotometric Grade; Ethanol, JIS special grade, 94.8-95.8%; FT-0625729; FT-0625731; FT-0625732; FT-0668048; Ethanol, >=99.5%, SAJ super special grade; PM-6193-200; Reagent Alcohol, anhydrous, <=0.003% water; Reagent Alcohol, anhydrous, <=0.005% water; C00469; D00068; Ethanol, >=99.5%, suitable for fluorescence; Ethanol, Alcohol Reagent, anhydrous, denatured; Ethyl Alcohol 95% (Grain Derived) FCC Grade; Ethyl Alcohol 95% (Synthetic) ACS/USP Grade; Ethanol, >10 - 24% in a non hazardous diluent; Ethanol, >24 - 50% in a non hazardous diluent; Ethyl Alcohol Absolute (Synthetic) ACS/USP Grade; SR-01000944357; Ethanol, puriss. p.a., absolute, >=99.8% (GC); SR-01000944357-1; Ethanol, denatured (5 % IPA, 5 % n-propylacetate); Reagent Alcohol, used for histology tissue preparation; Ethanol, anhydrous, denatured, Spectrophotometric Grade; Ethyl alcohol, Pure, 190 proof, for molecular biology; Ethyl alcohol, Pure, 200 proof, anhydrous, >=99.5%; Ethyl alcohol, Pure, 200 proof, for molecular biology; Ethanol, absolute, >=99.8% (GC), sales not in Germany; Ethyl Alcohol Absolute (Dehydrated) USP, BP/EP, JP Grade; Ethyl alcohol, Pure, 200 proof, ACS reagent, >=99.5%; Reagent Alcohol, 70%, used for histology tissue preparation; Reagent Alcohol, 80%, used for histology tissue preparation; 1E37B0D2-6209-4B03-A57D-500F3223C2DA; Alcohol, United States Pharmacopeia (USP) Reference Standard; Ethanol, >=99.5%, suitable for absorption spectrum analysis; Ethanol-water solutions, NIST(R) SRM(R) 1828b, six levels; Ethyl alcohol, Pure, 200 proof, HPLC/spectrophotometric grade; Reagent Alcohol, 95%, Used for histology tissue preparation; Ethanol solution, NIST(R) SRM(R) 2897a, nominal mass fraction 2%; Ethanol solution, NIST(R) SRM(R) 2898a, nominal mass fraction 6%; Ethanol solution, NIST(R) SRM(R) 2899a, nominal 25% by mass; Ethanol, p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.9%; Ethanol, suitable for 300 per JIS, >=99.5%, for residue analysis; Ethyl alcohol, Pure, 190 proof, meets USP testing specifications; Ethyl alcohol, Pure, 200 proof, anhydrous, ZerO2(TM), >=99.5%; Ethyl alcohol, Pure, 200 proof, meets USP testing specifications; Specially Denatured Alcohol, 190 proof, SDA 23A, contains Acetone; Specially Denatured Alcohol, 190 proof, SDA 2B-3, contains Toluene; Specially Denatured Alcohol, 190 proof, SDA 30, contains Methanol; Specially Denatured Alcohol, 190 proof, SDA 3A, contains Methanol; Specially Denatured Alcohol, 200 proof, SDA 23A, contains Acetone; Specially Denatured Alcohol, 200 proof, SDA 2B-3, contains Toluene; Specially Denatured Alcohol, 200 proof, SDA 30, contains Methanol; Specially Denatured Alcohol, 200 proof, SDA 3A, contains Methanol; Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material; Dehydrated Alcohol, United States Pharmacopeia (USP) Reference Standard; Ethanol Fixative 80% v/v, suitable for fixing solution (blood films); Ethanol solution, certified reference material, 2000 mug/mL in methanol; Ethanol standards 10% (v/v), 10 % (v/v) in H2O, analytical standard; Ethanol, absolute, for gradient elution, sales not in Germany, >=99.9%; Ethanol, absolute, for HPLC, sales not in Germany1, >=99.8% (GC); Ethanol, absolute, semiconductor grade PURANAL(TM) (Honeywell 17826); Ethanol, suitable for 1000 per JIS, >=99.5%, for residue analysis; Ethanol-water solution, NIST(R) SRM(R) 2894, nominal mass fraction 0.1%; Ethanol-water solution, NIST(R) SRM(R) 2895, nominal mass fraction 0.2%; Ethanol-water solution, NIST(R) SRM(R) 2896, nominal mass fraction 0.3%; Ethanol-water solution, NIST(R) SRM(R) 2900, nominal 95.6% by mass; Ethyl Alcohol Absolute (Dehydrated, Synthetic) USP, BP/EP, JP Grade; Ethyl alcohol, Pure, 140 proof, Excise Tax-free, Permit for use required; Ethyl alcohol, Pure, 160 proof, Excise Tax-free, Permit for use required; Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%; Specially Denatured Alcohol, 190 proof, SDA 2B-4, contains Heptanes; Specially Denatured Alcohol, 190 proof, SDA 2B-4, contains n-Heptane; Specially Denatured Alcohol, 190 proof, SDA 2B-5, contains n-Hexane; Specially Denatured Alcohol, 190 proof, SDA 35A, contains Ethyl acetate; Specially Denatured Alcohol, 190 proof, SDA 3C, contains Isopropanol; Specially Denatured Alcohol, 200 proof, SDA 2B-4, contains Heptanes; Specially Denatured Alcohol, 200 proof, SDA 2B-4, contains n-Heptane; Specially Denatured Alcohol, 200 proof, SDA 2B-5, contains n-Hexane; Specially Denatured Alcohol, 200 proof, SDA 35A, contains Ethyl acetate; Specially Denatured Alcohol, 200 proof, SDA 3C, contains
• Indication:
  In total 2 Indication(s)
  Chronic pain [ICD-11: MG30]; Approved; [1]
  Cystitis [ICD-11: GC00]; Approved; [1]
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Alcoholic liver disease [ICD-11: DB94]; [1]
• Target: GABA(A) receptor alpha-1 (GABRA1); GBRA1_HUMAN; [1]
• IsoSMILES: CCO
• InChI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
• InChIKey: LFQSCWFLJHTTHZ-UHFFFAOYSA-N
• PubChem CID: 702
• ChEBI ID: CHEBI:16236
• TTD Drug ID: D00AMQ
• VARIDT ID: DR0655
• INTEDE ID: DR00377
• DrugBank ID: DB00898

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-13: Digestive system diseases

Alcoholic liver disease [ICD-11: DB94]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: X inactive specific transcript (XIST) [1]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Liver fibrogenesis [ICD-11: DB94.Y]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HSCs; N.A.; .; N.A.
• In Vivo Model: male C57BL/6 mice model; Mus musculus
• Experiment for Molecule Alteration: Mimic assay; Luciferase assay; qRT-PCR; Western bloting analysis
• Experiment for Drug Resistance: MTT assay; Dual luciferase reporter assay
• Mechanism Description: XIST enhances ethanol-induced HSCs autophagy and activation via miR-29b/HMGB1 axis.

References

• Ref 1: Long noncoding RNA XIST enhances ethanol-induced hepatic stellate cells autophagy and activation via miR-29b/HMGB1 axisIUBMB Life. 2019 Dec;71(12):1962-1972. doi: 10.1002/iub.2140. Epub 2019 Aug 16.