Drug Information

Drug (ID: DG01761) and It's Reported Resistant Information

Name	MK2206/Vemurafenib
Synonyms	MK2206/Vemurafenib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Melanoma [ICD-11: 2C30]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)				[1]
Molecule Alteration	Missense mutation		p.V600X (c.1798_1800)	Molecule Info
Sensitive Disease	Melanoma [ICD-11: 2C30.0]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	A375 cells	Skin	Homo sapiens (Human)	CVCL_0132
	Melanoma cells	Skin	Homo sapiens (Human)	N.A.
	WM cells	N.A.	Homo sapiens (Human)	N.A.
	SK cells	Brain	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	CellTiter-Glo assay; Fluorescent microscopy assay; Apoptosis analysis

References

Ref 1	A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibitionCancer Discov. 2014 Jan;4(1):69-79. doi: 10.1158/2159-8290.CD-13-0279. Epub 2013 Nov 21.

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