Drug (ID: DG01760) and It's Reported Resistant Information
Name
Buparlisib/Vemurafenib
Synonyms
Buparlisib/Vemurafenib
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Melanoma [ICD-11: 2C30]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF) [1]
Molecule Alteration Missense mutation
p.V600X (c.1798_1800)
Sensitive Disease Melanoma [ICD-11: 2C30.0]
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model A375 cells Skin Homo sapiens (Human) CVCL_0132
Melanoma cells Skin Homo sapiens (Human) N.A.
WM cells N.A. Homo sapiens (Human) N.A.
SK cells Brain Homo sapiens (Human) N.A.
Experiment for
Molecule Alteration
Western blotting analysis
Experiment for
Drug Resistance
CellTiter-Glo assay; Fluorescent microscopy assay; Apoptosis analysis
References
Ref 1 A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibitionCancer Discov. 2014 Jan;4(1):69-79. doi: 10.1158/2159-8290.CD-13-0279. Epub 2013 Nov 21.

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