Drug Information
Drug (ID: DG01760) and It's Reported Resistant Information
Name |
Buparlisib/Vemurafenib
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Synonyms |
Buparlisib/Vemurafenib
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Target | . | NOUNIPROTAC | [1] |
Type(s) of Resistant Mechanism of This Drug
ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Melanoma [ICD-11: 2C30]
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF) | [1] | |||
Molecule Alteration | Missense mutation | p.V600X (c.1798_1800) |
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Sensitive Disease | Melanoma [ICD-11: 2C30.0] | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | A375 cells | Skin | Homo sapiens (Human) | CVCL_0132 |
Melanoma cells | Skin | Homo sapiens (Human) | N.A. | |
WM cells | N.A. | Homo sapiens (Human) | N.A. | |
SK cells | Brain | Homo sapiens (Human) | N.A. | |
Experiment for Molecule Alteration |
Western blotting analysis | |||
Experiment for Drug Resistance |
CellTiter-Glo assay; Fluorescent microscopy assay; Apoptosis analysis |
References
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