Drug Information

Drug (ID: DG01758) and It's Reported Resistant Information

Name	Ganetespib/TAK-733
Synonyms	Ganetespib/TAK-733 Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Melanoma [ICD-11: 2C30]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)				[1]
Molecule Alteration	Missense mutation		p.V600E (c.1799T>A)	Molecule Info
Sensitive Disease	Melanoma [ICD-11: 2C30.0]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Ba/F3 cells	Colon	Homo sapiens (Human)	CVCL_0161
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	WST-1 cell proliferation assay

References

Ref 1	Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespibMol Cancer Ther. 2014 Feb;13(2):353-63. doi: 10.1158/1535-7163.MCT-13-0481. Epub 2014 Jan 7.

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