Drug Information

Drug (ID: DG01755) and It's Reported Resistant Information

Name	Trametinib/Vemurafenib
Synonyms	Trametinib/Vemurafenib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Neuroendocrine carcinoma [ICD-11: 2D4Y]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)			[1]
Molecule Alteration	Missense mutation	p.V600E (c.1799T>A)	Molecule Info
Sensitive Disease	Metastatic neuroendocrine carcinoma [ICD-11: 2D4Y.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data

References

Ref 1	BRAFV600E Mutations in High-Grade Colorectal Neuroendocrine Tumors May Predict Responsiveness to BRAF-MEK Combination TherapyCancer Discov. 2016 Jun;6(6):594-600. doi: 10.1158/2159-8290.CD-15-1192. Epub 2016 Apr 5.

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