Drug Information

Drug (ID: DG01742) and It's Reported Resistant Information

Name	Binimetinib/Cetuximab/Encorafenib
Synonyms	Binimetinib/Cetuximab/Encorafenib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)			[1]
Molecule Alteration	Missense mutation	p.V600E (c.1799T>A)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]		Disease Info
Experimental Note	Identified from the Human Clinical Data

References

Ref 1	Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal CancerN Engl J Med. 2019 Oct 24;381(17):1632-1643. doi: 10.1056/NEJMoa1908075. Epub 2019 Sep 30.

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