Drug Information

Drug (ID: DG01727) and It's Reported Resistant Information

Name	JQ1/Osimertinib
Synonyms	JQ1/Osimertinib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Solid tumour/cancer [ICD-11: 2A00-2F9Z]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Receptor tyrosine-protein kinase erbB-2 (ERBB2)				[1]
Molecule Alteration	IF-insertion		p.Y772_A775dupYVMA (c.2325_2326insTATGTAATGGCA)	Molecule Info
Sensitive Disease	Solid tumour/cancer [ICD-11: 2A00-2F9Z]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Ba/F3 cells	Colon	Homo sapiens (Human)	CVCL_0161
	NCI-H1781 cells	Pleural effusion	Homo sapiens (Human)	CVCL_1494
Experiment for Molecule Alteration	Western blotting analysis; Immunohistochemistry; H&E staining assay
Experiment for Drug Resistance	CCK-8 assay

References

Ref 1	Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with OsimertinibClin Cancer Res. 2018 Jun 1;24(11):2594-2604. doi: 10.1158/1078-0432.CCR-17-1875. Epub 2018 Jan 3.

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