Drug Information

Drug (ID: DG01722) and It's Reported Resistant Information
Name
MK-2206/PD184352
Synonyms
MK-2206/PD184352
    Click to Show/Hide
Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Click to Show/Hide the Resistance Disease of This Class
Melanoma [ICD-11: 2C30]
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Phosphatase and tensin homolog (PTEN) [1]
Molecule Alteration FS-deletion
p.V317fs (c.950_953)
 Molecule Info 
Sensitive Disease Melanoma [ICD-11: 2C30.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model A375 cells Skin Homo sapiens (Human) CVCL_0132
Experiment for
Molecule Alteration		 Sanger sequencing assay; SNP array; qPCR
Experiment for
Drug Resistance		 CellTiter-Glo assay
References
Ref 1 Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibitionAnn Oncol. 2014 May;25(5):959-67. doi: 10.1093/annonc/mdu049. Epub 2014 Feb 6.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.