Drug Information
Drug (ID: DG01707) and It's Reported Resistant Information
Type(s) of Resistant Mechanism of This Drug
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Sarcoma [ICD-11: 2C35]
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Epigenetic Alteration of DNA, RNA or Protein (EADR) | ||||
Key Molecule: Oxalosuccinate decarboxylase (IDH1) | [1] | |||
Molecule Alteration | Missense mutation | p.R132C (c.394C>T) |
||
Resistant Disease | Sarcoma [ICD-11: 2C35.0] | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | IDH2 cells | N.A. | Homo sapiens (Human) | N.A. |
IDH1 cells | N.A. | Homo sapiens (Human) | N.A. | |
In Vivo Model | Female athymic nu/nu mouse PDX model | Mus musculus | ||
Experiment for Drug Resistance |
Promega assay | |||
Mechanism Description | The oncometabolite, 2-hydroxyglutarate, renders IDH1/2 mutant cancer cells deficient in homologous recombination and confers vulnerability to synthetic lethal targeting with PARP inhibitors. |
References
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