Drug Information

Drug (ID: DG01693) and It's Reported Resistant Information
Name
Buparlisib/Paclitaxel
Synonyms
Buparlisib/Paclitaxel
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Breast cancer [ICD-11: 2C60]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: PI3-kinase alpha (PIK3CA) [1]
Molecule Alteration Missense mutation
p.H1047R (c.3140A>G)
 Molecule Info 
Sensitive Disease Breast adenocarcinoma [ICD-11: 2C60.1]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
References
Ref 1 PI3K inhibitor provides durable response in metastatic metaplastic carcinoma of the breast: A hidden gem in the BELLE-4 studyJ Formos Med Assoc. 2019 Sep;118(9):1333-1338. doi: 10.1016/j.jfma.2018.12.004. Epub 2018 Dec 18.

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