Drug Information

Drug (ID: DG01675) and It's Reported Resistant Information
Name
AMGMDS3
Synonyms
AMGMDS3; Q59770979
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Structure
Drug Resistance Disease(s)
Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
[1]
Target . NOUNIPROTAC [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
9
IsoSMILES
CC[C@@H](C(=O)OCC)N1[C@@H]([C@H]([C@](CC1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC(=CC=C3)Cl
InChI
InChI=1S/C26H29Cl2NO5/c1-4-20(25(33)34-5-2)29-21(30)14-26(3,15-22(31)32)23(16-8-6-10-18(27)12-16)24(29)17-9-7-11-19(28)13-17/h6-13,20,23-24H,4-5,14-15H2,1-3H3,(H,31,32)/t20-,23+,24+,26-/m0/s1
InChIKey
SZACTBIUKXKQGM-YLJDOISLSA-N
PubChem CID
139033635
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Click to Show/Hide the Resistance Disease of This Class
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.V157F (c.469G>T)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.V157F (c.469G>T) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R158H (c.473G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R158H (c.473G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R158L (c.473G>T)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R158L (c.473G>T) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175H (c.524G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R175H (c.524G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.Y220C (c.659A>G)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.Y220C (c.659A>G) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.G245S (c.733G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.G245S (c.733G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R248W (c.742C>T)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R248W (c.742C>T) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R248Q (c.743G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R248Q (c.743G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R249S (c.747G>C)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R249S (c.747G>C) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R273C (c.817C>T)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R273C (c.817C>T) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R273H (c.818G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R273H (c.818G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R280K (c.839G>A)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R280K (c.839G>A) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R280T (c.839G>C)
 Molecule Info 
Resistant Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HCT116 cells Colon Homo sapiens (Human) CVCL_0291
Capan-2 cells Pancreas Homo sapiens (Human) CVCL_0026
MDA-MB-453 cells Breast Homo sapiens (Human) CVCL_0418
MG-63 cells Bone Homo sapiens (Human) CVCL_0426
NCI-H82 cells Pleural effusion Homo sapiens (Human) CVCL_1591
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 Fluorescence microscopy assay
Mechanism Description The missense mutation p.R280T (c.839G>C) in gene TP53 cause the resistance of AMGMDS3 by unusual activation of pro-survival pathway
References
Ref 1 Identifying the determinants of response to MDM2 inhibitionOncotarget. 2015 Apr 10;6(10):7701-12. doi: 10.18632/oncotarget.3116.

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