Drug Information

Drug (ID: DG01655) and It's Reported Resistant Information

• Name: SBI-0640756
• Synonyms: SBI-0640756; 1821280-29-8; SCHEMBL19857722; SCHEMBL19857734; SBI-756; BCP23633; EX-A2800; WXC28029; s8181; ZINC521836536; CCG-268701; CS-5696; SBI0640756; SBI 0640756; BS-15707; HY-19560; D80610; SBI-0640756, >=98% (HPLC); SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756; (E)-6-Chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one; 6-chloro-3-[(E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
• Target: .; NOUNIPROTAC; [1]
• Formula: 4
• IsoSMILES: C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)/C=C/C4=CC(=CN=C4)F
• InChI: InChI=1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
• InChIKey: VVWGPQZBDQVQRC-RMKNXTFCSA-N
• PubChem CID: 121241171

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Melanoma [ICD-11: 2C30]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Serine/threonine-protein kinase B-raf (BRAF) [1]

• Molecule Alteration: Missense mutation; p.V600E (c.1799T>A)
• Sensitive Disease: Melanoma [ICD-11: 2C30.0]
• Experimental Note: Identified from the Human Clinical Data

References

• Ref 1: SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation ComplexCancer Res. 2015 Dec 15;75(24):5211-8. doi: 10.1158/0008-5472.CAN-15-0885. Epub 2015 Nov 24.