Drug Information

Drug (ID: DG01558) and It's Reported Resistant Information

Name	II-B08
Synonyms	1143579-78-5; II-B08; CHEMBL590043; 3-(1-(3-([1,1'-Biphenyl]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1h-indole-5-carboxylic acid; 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid; 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic Acid; SCHEMBL13883165; II- B08; BDBM50308158; MFCD32645102; F51980; Q27461817; 3-(1-(3-([1,1'-BiPh]-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-Ph-1H-indole-5-carboxylic acid; 6-hydroxy-1-methyl-3-[1-[3-oxo-3-(4-phenylanilino)propyl]triazol-4-yl]-2-phenylindole-5-carboxylic acid; JZG Click to Show/Hide
Structure
Target	.	NOUNIPROTAC	[1]
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Formula	8
IsoSMILES	CN1C2=CC(=C(C=C2C(=C1C3=CC=CC=C3)C4=CN(N=N4)CCC(=O)NC5=CC=C(C=C5)C6=CC=CC=C6)C(=O)O)O
InChI	InChI=1S/C33H27N5O4/c1-37-28-19-29(39)26(33(41)42)18-25(28)31(32(37)23-10-6-3-7-11-23)27-20-38(36-35-27)17-16-30(40)34-24-14-12-22(13-15-24)21-8-4-2-5-9-21/h2-15,18-20,39H,16-17H2,1H3,(H,34,40)(H,41,42)
InChIKey	RATFAFAWIWHLMR-UHFFFAOYSA-N
PubChem CID	25262527

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Hematologic cancer [ICD-11: 2B3Z]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)				[1]
Molecule Alteration	Missense mutation		p.E76K (c.226G>A)	Molecule Info
Sensitive Disease	Hematologic Cancer [ICD-11: MG24.Y]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HEK293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	3H-thymidine incorporation assay
Mechanism Description	The missense mutation p.E76K (c.226G>A) in gene PTPN11 cause the sensitivity of II-B08 by unusual activation of pro-survival pathway

References

Ref 1	Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)J Med Chem. 2010 Mar 25;53(6):2482-93. doi: 10.1021/jm901645u.