Drug Information

Drug (ID: DG01514) and It's Reported Resistant Information

Name	DEL-22379
Synonyms	DEL-22379; 181223-80-3; DEL22379; CHEBI:90905; AMY16577; EX-A1739; AKOS027470285; ZINC137055150; CCG-269173; CS-5355; (Z)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide; CID 11224574; HY-18932; Q21044462; 181222-54-8; N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide; N-{(3Z)-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-2,3-dihydro-1H-indol-5-yl}-3-(piperidin-1-yl)propanamide; N-{(3Z)-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-2,3-dihydro-1H-indol-5-yl}-3-(piperidin-1-yl)propionamide Click to Show/Hide
Structure
Target	.	NOUNIPROTAC	[1]
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Formula	6
IsoSMILES	COC1=CC2=C(C=C1)NC=C2/C=C\\3/C4=C(C=CC(=C4)NC(=O)CCN5CCCCC5)NC3=O
InChI	InChI=1S/C26H28N4O3/c1-33-19-6-8-23-20(15-19)17(16-27-23)13-22-21-14-18(5-7-24(21)29-26(22)32)28-25(31)9-12-30-10-3-2-4-11-30/h5-8,13-16,27H,2-4,9-12H2,1H3,(H,28,31)(H,29,32)/b22-13-
InChIKey	INQUULPXCZAKMS-XKZIYDEJSA-N
PubChem CID	11224574

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)				[1]
Molecule Alteration	Missense mutation		p.V600E (c.1799T>A)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
	A375 cells	Skin	Homo sapiens (Human)	CVCL_0132
In Vivo Model	Female athymic nu/nu mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	Caspase-Glo 3/7 luminogenic assay

Melanoma [ICD-11: 2C30]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Serine/threonine-protein kinase B-raf (BRAF)				[1]
Molecule Alteration	Missense mutation		p.V600E (c.1799T>A)	Molecule Info
Sensitive Disease	Melanoma [ICD-11: 2C30.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
	A375 cells	Skin	Homo sapiens (Human)	CVCL_0132
In Vivo Model	Female athymic nu/nu mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	Caspase-Glo 3/7 luminogenic assay

References

Ref 1	Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway OncogenesCancer Cell. 2015 Aug 10;28(2):170-82. doi: 10.1016/j.ccell.2015.07.001.