Drug Information
Drug (ID: DG01492) and It's Reported Resistant Information
Name |
NSC59984
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Synonyms |
NSC59984; 803647-40-7; NSC 59984; (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one; NSC-59984; MLS000737358; SMR000528276; 1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one; CHEMBL1979662; SCHEMBL17071991; SCHEMBL17654893; BDBM96260; cid_5356520; EX-A776; HMS2885J20; BCP16647; MFCD29905462; s8106; ZINC59727553; NSC59984,NCI59984; CCG-267098; CS-5382; AC-32965; BS-18159; HY-19726; NSC59984, >=98% (HPLC); A13413; J-690353; (E)-1-(4-methylpiperazino)-3-(5-nitro-2-furyl)prop-2-en-1-one; (E)-1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one; N-[1,3-Dimethyl-2-oxo-6-(1-pyrrolidinyl)-2,3-dihydro-1H-benzimidazol-5-yl]-2-methoxybenzamide
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Structure | |||||
Target | . | NOUNIPROTAC | [1] | ||
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Formula |
2
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IsoSMILES |
CN1CCN(CC1)C(=O)/C=C/C2=CC=C(O2)[N+](=O)[O-]
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InChI |
InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
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InChIKey |
QKTRIGNWBRHBFV-DUXPYHPUSA-N
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PubChem CID |
Type(s) of Resistant Mechanism of This Drug
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Colorectal cancer [ICD-11: 2B91]
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R175H (c.524G>A) |
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Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | SW480 cells | Colon | Homo sapiens (Human) | CVCL_0546 |
HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |
DLD-1 cells | Colon | Homo sapiens (Human) | CVCL_0248 | |
RXF393 cells | Kidney | Homo sapiens (Human) | CVCL_1673 | |
MRC5 cells | Fetal lung | Homo sapiens (Human) | CVCL_0440 | |
Wi38 cells | Fetal lung | Homo sapiens (Human) | CVCL_0579 | |
Hop92 cells | Lung | Homo sapiens (Human) | CVCL_1286 | |
In Vivo Model | Female CRL nude mouse xenograft model | Mus musculus | ||
Experiment for Molecule Alteration |
Semi-quantitative RT-PCR; Western blotting analysis | |||
Experiment for Drug Resistance |
CellTiter-Glo assay; Colony formation assay | |||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R175L (c.524G>T) |
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Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | SW480 cells | Colon | Homo sapiens (Human) | CVCL_0546 |
HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |
DLD-1 cells | Colon | Homo sapiens (Human) | CVCL_0248 | |
RXF393 cells | Kidney | Homo sapiens (Human) | CVCL_1673 | |
MRC5 cells | Fetal lung | Homo sapiens (Human) | CVCL_0440 | |
Wi38 cells | Fetal lung | Homo sapiens (Human) | CVCL_0579 | |
Hop92 cells | Lung | Homo sapiens (Human) | CVCL_1286 | |
In Vivo Model | Female CRL nude mouse xenograft model | Mus musculus | ||
Experiment for Molecule Alteration |
Semi-quantitative RT-PCR; Western blotting analysis | |||
Experiment for Drug Resistance |
CellTiter-Glo assay; Colony formation assay |
References
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