Drug Information

Drug (ID: DG01491) and It's Reported Resistant Information
Name
NSC319726
Synonyms
NSC319726; 71555-25-4; NSC 319726; CID 5351307; N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide; N-[(E)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide; (E)-N'-(1-(pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide; NSC-319726; MLS002703052; AZETIDINE CARBOTHIOIC ACID, [1-(2-PYRIDINYL)ETHYLIDENE]HYDRAZIDE; CHEMBL1976486; SCHEMBL17975335; Azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene] hydrazide; EX-A2113; WCA55525; 2597AH; CCG-35689; s7149; ZINC17122727; AKOS024458479; CS-3542; AC-32867; AS-56104; HY-18634; LS-13960; A899911; BRD-K99170882-001-01-9; Azetidine-1-carbothioic acid(1-pyridin-2-yl-ethylidene)hydrazide
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Structure
Drug Resistance Disease(s)
Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
Breast cancer [ICD-11: 2C60]
[1]
Target . NOUNIPROTAC [1]
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Formula
2
IsoSMILES
C/C(=N\\NC(=S)N1CCC1)/C2=CC=CC=N2
InChI
InChI=1S/C11H14N4S/c1-9(10-5-2-3-6-12-10)13-14-11(16)15-7-4-8-15/h2-3,5-6H,4,7-8H2,1H3,(H,14,16)/b13-9+
InChIKey
XDHBUMNIQRLHGO-UKTHLTGXSA-N
PubChem CID
5351307
Type(s) of Resistant Mechanism of This Drug
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Click to Show/Hide the Resistance Disease of This Class
Lung cancer [ICD-11: 2C25]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175L (c.524G>T)
 Molecule Info 
Sensitive Disease Lung adenocarcinoma [ICD-11: 2C25.0]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model (MEF) (10)3 cells N.A. Mus musculus (Mouse) N.A.
Experiment for
Molecule Alteration		 Western blotting analysis
Experiment for
Drug Resistance		 MTS assay
Mechanism Description The missense mutation p.R175L (c.524G>T) in gene TP53 cause the sensitivity of NSC319726 by aberration of the drug's therapeutic target
Breast cancer [ICD-11: 2C60]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R273W (c.817_819delCGTinsTGG)
 Molecule Info 
Resistant Disease Breast adenocarcinoma [ICD-11: 2C60.1]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model (MEF) (10)3 cells N.A. Mus musculus (Mouse) N.A.
Experiment for
Molecule Alteration		 Western blotting analysis
Experiment for
Drug Resistance		 MTS assay
Mechanism Description The missense mutation p.R273W (c.817_819delCGTinsTGG) in gene TP53 cause the resistance of NSC319726 by aberration of the drug's therapeutic target
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175H (c.524G>A)
 Molecule Info 
Sensitive Disease Breast adenocarcinoma [ICD-11: 2C60.1]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model (MEF) (10)3 cells N.A. Mus musculus (Mouse) N.A.
Experiment for
Molecule Alteration		 Western blotting analysis
Experiment for
Drug Resistance		 MTS assay
Mechanism Description The missense mutation p.R175H (c.524G>A) in gene TP53 cause the sensitivity of NSC319726 by aberration of the drug's therapeutic target
Ovarian cancer [ICD-11: 2C73]
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175H (c.524G>A)
 Molecule Info 
Sensitive Disease Ovarian cancer [ICD-11: 2C73.0]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model (MEF) (10)3 cells N.A. Mus musculus (Mouse) N.A.
Experiment for
Molecule Alteration		 Western blotting analysis
Experiment for
Drug Resistance		 MTS assay
Mechanism Description The missense mutation p.R175H (c.524G>A) in gene TP53 cause the sensitivity of NSC319726 by aberration of the drug's therapeutic target
References
Ref 1 Allele-specific p53 mutant reactivationCancer Cell. 2012 May 15;21(5):614-625. doi: 10.1016/j.ccr.2012.03.042.

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