Drug Information

Drug (ID: DG00598) and It's Reported Resistant Information

• Name: SL111
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Mycosis fungoides [ICD-11: 2B01]; [1]
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Mycosis fungoides [ICD-11: 2B01]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: hsa-mir-155 [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Mycosis fungoides [ICD-11: 2B01.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: MyLa cells; Embryo; Homo sapiens (Human); N.A.
• In Vitro Model: MJ cells; Peripheral blood; Homo sapiens (Human); CVCL_1414
• In Vivo Model: SCID nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: Oncogenic miR-155 appears to contribute to the cancerous phenotype of MyLa and MJ cells.

Key Molecule: hsa-mir-155 [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Mycosis fungoides [ICD-11: 2B01.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: MyLa cells; Embryo; Homo sapiens (Human); N.A.
• In Vitro Model: MJ cells; Peripheral blood; Homo sapiens (Human); CVCL_1414
• In Vivo Model: SCID nude mouse xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: Oncogenic miR-155 appears to contribute to the cancerous phenotype of MyLa and MJ cells.

References

• Ref 1: Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study .Br J Dermatol. 2017 Sep;177(3):791-800. doi: 10.1111/bjd.15422. Epub 2017 May 7. 10.1111/bjd.15422