Drug Information

Drug (ID: DG00586) and It's Reported Resistant Information

• Name: Corticosteroids
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
  Inflammatory bowel diseases [ICD-11: DD72]; [1]
  Lupus erythematosus [ICD-11: 4A40]; [2]
• Target: .; NOUNIPROTAC; [2]
• TTD Drug ID: D0B4ML

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-04: Immune system diseases

Lupus erythematosus [ICD-11: 4A40]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [2]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Lupus erythematosus [ICD-11: 4A40.0]
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: Flow cytometry assay
• Mechanism Description: Several studies on patients with systemic autoimmune diseases in particular SLE, RA and PsA have demonstrated a significant correlation between P-gp expression/function, disease activity and the development of resistance to immunosuppressive therapy.

Key Molecule: Multidrug resistance protein 1 (ABCB1) [2]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Lupus erythematosus [ICD-11: 4A40.0]
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: Flow cytometry assay
• Mechanism Description: Several studies on patients with systemic autoimmune diseases in particular SLE, RA and PsA have demonstrated a significant correlation between P-gp expression/function, disease activity and the development of resistance to immunosuppressive therapy.

References

• Ref 1: Drug resistance in inflammatory bowel diseases .Curr Opin Pharmacol. 2015 Dec;25:56-61. doi: 10.1016/j.coph.2015.11.003. Epub 2015 Nov 29. 10.1016/j.coph.2015.11.003
• Ref 2: P-glycoprotein and drug resistance in systemic autoimmune diseases .Int J Mol Sci. 2014 Mar 20;15(3):4965-76. doi: 10.3390/ijms15034965. 10.3390/ijms15034965