Drug Information
Drug (ID: DG00500) and It's Reported Resistant Information
Type(s) of Resistant Mechanism of This Drug
ADTT: Aberration of the Drug's Therapeutic Target
DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-01: Infectious/parasitic diseases
Salmonellosis [ICD-11: 1A09]
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Key Molecule: Catalase isozyme A/Tetracycline efflux MFS transporter/Dihydropteroate synthase (CATA1/TETB/SUL) | [1] | |||
Molecule Alteration | Expression | Inherence |
||
Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Salmonella agona 231 | 58095 | ||
Experiment for Molecule Alteration |
PCR screening assay | |||
Experiment for Drug Resistance |
Disc diffusion assay | |||
Mechanism Description | The multiresistance plasmid from S. Agona strain 231 carried the chloramphenicol resistance gene catA1 coding for a type A chloramphenicol acetyltransferase and the resistance gene tet(B) coding for a tetracycline/minocycline exporter. This plasmid also harboured the streptomycin resistance gene strA coding for an aminoglycoside phosphotransferase and the sulphonamide resistance gene sul1 which represents part of the 3' conserved segment of class 1 integrons. |
Pasteurellosis [ICD-11: 1B99]
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Drug Inactivation by Structure Modification (DISM) | ||||
Key Molecule: Erm methyltransferase (ERM42) | [2] | |||
Molecule Alteration | Expression | Inherence |
||
Resistant Disease | Pasteurella multocida infection [ICD-11: 1B99.0] | |||
Experimental Note | Discovered Using In-vivo Testing Model | |||
In Vitro Model | Escherichia coli ATCC 25922 | 1322345 | ||
Staphylococcus aureus ATCC 29213 | 1280 | |||
Pasteurella multocida 36950 | 1075089 | |||
Experiment for Molecule Alteration |
Whole genome sequence assay; Allelic frequency measurement assay | |||
Experiment for Drug Resistance |
Broth microdilution method assay | |||
Mechanism Description | The analysis of one representative P. multocida isolate identified an 82 kb integrative and conjugative element (ICE) integrated into the chromosomal DNA. This ICE, designated ICEPmu1, harboured 11 resistance genes, which confer resistance to streptomycin/spectinomycin (aadA25), streptomycin (strA and strB), gentamicin (aadB), kanamycin/neomycin (aphA1), tetracycline [tetR-tet(H)], chloramphenicol/florfenicol (floR), sulphonamides (sul2), tilmicosin/clindamycin [erm(42)] or tilmicosin/tulathromycin [msr(E)-mph(E)]. |
References
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