Drug Information

Drug (ID: DG00480) and It's Reported Resistant Information

• Name: BPI-derived peptide P2
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
  Cholera [ICD-11: 1A00]; [1], [2]
  COVID-19 [ICD-11: 1D92]; [3]

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Cholera [ICD-11: 1A00]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Outer membrane protein U (OMPU) [1], [2]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Vibrio cholerae infection [ICD-11: 1A00.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Vibrio cholerae N16961; 243277
• In Vitro Model: Vibrio cholerae O395; 345073
• Experiment for Molecule Alteration: Whole genome sequence assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: BPI and P2, a peptide that contains BPI residues 86 to 104, may employ the same mechanism for killing Escherichia coli since both increase outer membrane (OM) permeability to hydrophobic compounds and inhibit O2 consumption.The ompU mutant was more sensitive to P2 because it possessed a more fragile OM than did wt cells.

References

• Ref 1: The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. Infect Immun. 2004 Jun;72(6):3577-83. doi: 10.1128/IAI.72.6.3577-3583.2004.
• Ref 2: OmpU as a biomarker for rapid discrimination between toxigenic and epidemic Vibrio cholerae O1/O139 and non-epidemic Vibrio cholerae in a modified MALDI-TOF MS assay. BMC Microbiol. 2014 Jun 18;14:158. doi: 10.1186/1471-2180-14-158.
• Ref 3: Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 Nature. 2021 May;593(7857):130-135. doi: 10.1038/s41586-021-03398-2. Epub 2021 Mar 8.