Drug Information

Drug (ID: DG00415) and It's Reported Resistant Information

Name	Cetrimide
Synonyms	Cetrimonium bromide; 57-09-0; Cetyltrimethylammonium bromide; Hexadecyltrimethylammonium bromide; CTAB; Centimide; CETAB; Bromat; Ctmab; Cee dee; Cetavlon; Hexadecyl trimethyl ammonium bromide; Trimethylcetylammonium bromide; Cetyl trimethyl ammonium bromide; Quamonium; Lissolamine; Cetaflon; Lauroseptol; Suticide; Pollacid; Cetarol; Micol; Cetrimide bp; Lissolamine A; Lissolamin V; Cetavlon bromide; Cycloton V; Cirrasol OD; Acetoquat CTAB; Softex KW; Cetrimonii bromidum; N-Cetyltrimethylammonium bromide; Bromuro de cetrimonio; Cetrimida Click to Show/Hide
Indication	In total 1 Indication(s) Skin and skin-structure infection [ICD-11: 1F28-1G0Z] Approved [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Staphylococcus meningitis [ICD-11: 1B54] [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C17H38BrN
IsoSMILES	CCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
InChI	1S/C17H38N.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18(2,3)4;/h5-17H2,1-4H3;1H/q+1;/p-1
InChIKey	CXRFDZFCGOPDTD-UHFFFAOYSA-M
PubChem CID	14250
ChEBI ID	CHEBI:3565
TTD Drug ID	D0U3IG
DrugBank ID	DB01718

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Click to Show/Hide the Resistance Disease of This Class

Staphylococcus meningitis [ICD-11: 1B54]

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Quinolone resistance protein NorB (NORB)			[1]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli		668369
Experiment for Molecule Alteration	DNA microarray hybridization assay
Experiment for Drug Resistance	Serial twofold agar dilutions assay
Mechanism Description	MgrA was an indirect regulator of norB expression. The mgrA norB double mutant was reproducibly twofold more susceptible to the tested quinolones than the mgrA mutant.
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Key Molecule: HTH-type transcriptional regulator MgrA (MGRA)			[1]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli		668369
Experiment for Molecule Alteration	DNA microarray hybridization assay
Experiment for Drug Resistance	Serial twofold agar dilutions assay
Mechanism Description	MgrA was an indirect regulator of norB expression. The mgrA norB double mutant was reproducibly twofold more susceptible to the tested quinolones than the mgrA mutant.

References

Ref 1	MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J Bacteriol. 2005 Apr;187(7):2395-405. doi: 10.1128/JB.187.7.2395-2405.2005.