Drug Information

Drug (ID: DG00413) and It's Reported Resistant Information

Name	Quinolones
Synonyms	AC1MI0KP Click to Show/Hide
Indication	In total 2 Indication(s) Bacterial infection [ICD-11: 1A00-1C4Z] Approved [1] HIV-infected patients with tuberculosis [ICD-11: 1B10-1B14] Approved [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Staphylococcus meningitis [ICD-11: 1B54] [1]
Target	DNA topoisomerase II (TOP2)	TOP2A_HUMAN ; TOP2B_HUMAN	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C9H7NO
IsoSMILES	C1=CC=C2C(=C1)C=CC(=O)N2
InChI	1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
InChIKey	LISFMEBWQUVKPJ-UHFFFAOYSA-N
PubChem CID	6038
ChEBI ID	CHEBI:16365
TTD Drug ID	D0Z3EI

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Click to Show/Hide the Resistance Disease of This Class

Staphylococcus meningitis [ICD-11: 1B54]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Quinolone resistance protein NorB (NORB)			[1]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli		668369
Experiment for Molecule Alteration	DNA microarray hybridization assay
Experiment for Drug Resistance	Serial twofold agar dilutions assay
Mechanism Description	MgrA was an indirect regulator of norB expression. The mgrA norB double mutant was reproducibly twofold more susceptible to the tested quinolones than the mgrA mutant.
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Key Molecule: HTH-type transcriptional regulator MgrA (MGRA)			[1]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli		668369
Experiment for Molecule Alteration	DNA microarray hybridization assay
Experiment for Drug Resistance	Serial twofold agar dilutions assay
Mechanism Description	MgrA was an indirect regulator of norB expression. The mgrA norB double mutant was reproducibly twofold more susceptible to the tested quinolones than the mgrA mutant.

References

Ref 1	MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J Bacteriol. 2005 Apr;187(7):2395-405. doi: 10.1128/JB.187.7.2395-2405.2005.