Drug Information

Drug (ID: DG00321) and It's Reported Resistant Information

Name	Beta-elemene
Synonyms	Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1R,2R,4S)-rel-; 33880-83-0; beta-Elemene, (-)-; (- )-bete-elemene; EINECS 251-713-0; AC1L1VID; Cyclohexane, 2,4-diisopropenyl-1-methyl-1-vinyl-, (1S,2S,4R)-; OPFTUNCRGUEPRZ-UHFFFAOYSA-N; Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1S-(1-alpha,2-beta,4-beta))-; (1alpha,2beta,4beta)-1-Methyl-2,4-bis(methylvinyl)-1-vinylcyclohexane; LS-56795; EN300-296339; 1-Methyl-1-vinyl-2,4-diisopropenylcyclohexane Click to Show/Hide
Indication	In total 1 Indication(s) Solid tumour/cancer [ICD-11: 2A00-2F9Z] Phase 1 [1], [2]
Structure
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Esophageal cancer [ICD-11: 2B70] [1], [2]
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Formula	C15H24
IsoSMILES	CC(=C)C1CCC(C(C1)C(=C)C)(C)C=C
InChI	1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3
InChIKey	OPFTUNCRGUEPRZ-UHFFFAOYSA-N
PubChem CID	10583
TTD Drug ID	D04VMG

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Esophageal cancer [ICD-11: 2B70]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: CDKN2B antisense RNA 1 (CDKN2B-AS1)				[1], [2]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Resistant Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.3]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell proliferation		Inhibition	hsa05200
In Vitro Model	ECA-109 cells	Esophagus	Homo sapiens (Human)	CVCL_6898
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Beta-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Telomerase reverse transcriptase (TERT)				[1], [2]
Molecule Alteration	Expression		Up-regulation	Molecule Info
Resistant Disease	Esophageal squamous cell carcinoma [ICD-11: 2B70.3]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell proliferation		Inhibition	hsa05200
In Vitro Model	ECA-109 cells	Esophagus	Homo sapiens (Human)	CVCL_6898
Experiment for Molecule Alteration	Western blot analysis; RT-qPCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Beta-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression.

References

Ref 1	Beta-Elemene inhibits the proliferation of esophageal squamous cell carcinoma by regulating long noncoding RNA-mediated inhibition of hTERT expression. Anticancer Drugs. 2015 Jun;26(5):531-9. doi: 10.1097/CAD.0000000000000216.
Ref 2	Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications. J Hematol Oncol. 2018 Sep 17;11(1):118. doi: 10.1186/s13045-018-0663-8.