Molecule Information

General Information of the Molecule (ID: Mol02159)
Name
H19, imprinted maternally expressed transcript (H19) ,Mus musculus
Synonyms
H19
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Molecule Type
LncRNA
Gene Name
H19
Gene ID
14955
Location
chr7:142,129,262-142,131,886[-]
Ensembl ID
ENSMUSG00000000031
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Insulin recombinant
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Type 2 diabetes mellitus [1]
Resistant Disease Type 2 diabetes mellitus [ICD-11: 5A11.0]
 Disease Info 
Resistant Drug Insulin recombinant
 Drug Info 
Molecule Alteration Down-regulation
Expression
Experimental Note Identified from the Human Clinical Data
In Vivo Model Male C57BL/6J mouse model Mus musculus
Experiment for
Drug Resistance		 Glucose tolerance test assay
Mechanism Description H19 LncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK.
References
Ref 1 H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPKDiabetes. 2018 Nov;67(11):2183-2198. doi: 10.2337/db18-0370. Epub 2018 Sep 10.

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