Drug Information

Drug (ID: DG00295) and It's Reported Resistant Information
Name
Benzoic acid
Synonyms
Phenylformate; benzoate anion; Benzoic acid, ion(1-); 766-76-7; Benzeneformate; Tennplas; Phenylcarboxylate; Benzenemethanoate; Retarded BA; Benzenecarboxylate; Phenyl carboxylic acid; benzoic acid anion; Oracyclic acid; 4-Carboxybenzenide; Benzene formic acid; AC1Q1HDY; AC1Q22CA; AC1L18SS; GTPL4565; DTXSID4043771; CHEBI:16150; BDBM36181; CTK2H9612; WPYMKLBDIGXBTP-UHFFFAOYSA-M; STL483236; ZINC328578076; NCGC00247905-01; ZB000218; CJ-00025; LS-190261; 3230-EP2374454A1; 3230-EP2372017A1; 3230-EP2316825A1; 3230-EP2316457A1
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Indication
In total 1 Indication(s)
Fungal infection [ICD-11: 1F29-1F2F]
Approved
[1]
Structure
Drug Resistance Disease(s)
Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (1 diseases)
Fungal infection [ICD-11: 1F29-1F2F]
[1]
Target Ras-related protein Rab-9A (RAB9A) RAB9A_HUMAN [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
C7H6O2
IsoSMILES
C1=CC=C(C=C1)C(=O)O
InChI
1S/C7H6O2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H,8,9)
InChIKey
WPYMKLBDIGXBTP-UHFFFAOYSA-N
PubChem CID
243
ChEBI ID
CHEBI:30746
TTD Drug ID
D0X9RY
DrugBank ID
DB03793
Type(s) of Resistant Mechanism of This Drug
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-01: Infectious/parasitic diseases
Click to Show/Hide the Resistance Disease of This Class
Fungal infection [ICD-11: 1F29-1F2F]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Polyamine transporter 1 (TPO1) [1]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Disease Fungal infection [ICD-11: 1F29-1F2F]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Saccharomyces cerevisiae 23344c 4932
Saccharomyces cerevisiae BY4741 1247190
Saccharomyces cerevisiae BY4741_gcn4del 1247190
Saccharomyces cerevisiae BY4741_pdr1del 1247190
Saccharomyces cerevisiae BY4741_pdr3del 1247190
Saccharomyces cerevisiae BY4741_pdr8del 1247190
Saccharomyces cerevisiae BY4741_stp1del 1247190
Saccharomyces cerevisiae BY4741_stp2del 1247190
Saccharomyces cerevisiae BY4741_tpo1del 1247190
Saccharomyces cerevisiae BY4741_war1del 1247190
Saccharomyces cerevisiae BY4741_yap1del 1247190
Saccharomyces cerevisiae BY4741_yap2del 1247190
Saccharomyces cerevisiae BY4741_yap3del 1247190
Saccharomyces cerevisiae BY4741_yap4del 1247190
Saccharomyces cerevisiae BY4741_yap5del 1247190
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 Benzoic acid susceptibility assay
Mechanism Description The Saccharomyces cerevisiae multidrug transporter Tpo1 was demonstrated to confer resistance to benzoic acid. TPO1 transcript levels were shown to be up-regulated in yeast cells suddenly exposed to this stress agent. This up-regulation is under the control of the Gcn4 and Stp1 transcription factors, involved in the response to amino acid availability, but not under the regulation of the multidrug resistance transcription factors Pdr1 and Pdr3 that have binding sites in TPO1 promoter.
References
Ref 1 Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1-regulated multidrug/multixenobiotic resistance transporter Tpo1. Appl Microbiol Biotechnol. 2017 Jun;101(12):5005-5018. doi: 10.1007/s00253-017-8277-6. Epub 2017 Apr 13.

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