Drug Information

Drug (ID: DG00218) and It's Reported Resistant Information

Name	Omacetaxine mepesuccinate
Synonyms	Synribo (TN) Click to Show/Hide
Indication	In total 1 Indication(s) Myeloproliferative neoplasm [ICD-11: 2A22] Approved [1]
Structure
Target	Ribosome A (hRA)	NOUNIPROTAC	[1]
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Formula	C29H39NO9
IsoSMILES	CC(C)(CCC[C@@](CC(=O)OC)(C(=O)O[C@H]1[C@H]2C3=CC4=C(C=C3CCN5[C@@]2(CCC5)C=C1OC)OCO4)O)O
InChI	1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1
InChIKey	HYFHYPWGAURHIV-JFIAXGOJSA-N
PubChem CID	285033
ChEBI ID	CHEBI:71019
TTD Drug ID	D0M4XY
DrugBank ID	DB04865

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Chronic myeloid leukemia [ICD-11: 2A20]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-370				[1]
Molecule Alteration	Expression		Up-regulation	Molecule Info
Sensitive Disease	Chronic myeloid leukemia [ICD-11: 2A20.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR370/FoxM1 signaling pathway		Regulation	hsa05206
In Vitro Model	K562 cells	Blood	Homo sapiens (Human)	CVCL_0004
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-370 sensitized k562 cells to HHT by inducing apoptosis in part by downregulation of FoxM1 expression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Forkhead box protein M1 (FOXM1)				[1]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Sensitive Disease	Chronic myeloid leukemia [ICD-11: 2A20.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR370/FoxM1 signaling pathway		Regulation	hsa05206
In Vitro Model	K562 cells	Blood	Homo sapiens (Human)	CVCL_0004
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	miR-370 sensitized k562 cells to HHT by inducing apoptosis in part by downregulation of FoxM1 expression.

References

Ref 1	MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1. J Transl Med. 2013 Oct 23;11:265. doi: 10.1186/1479-5876-11-265.