Drug Information

Drug (ID: DG00104) and It's Reported Resistant Information

Name	Lividomycin A
Synonyms	Lividomycin A; Lividomycin; Quintomycin B; Mannosyldeoxyparomomycin; Antibiotic 503-2; Antibiotic SF 767 A; Lividomycinum; Lividomycine; 36441-41-5; Lividomicina; SF 767 A; Livodymycin; Lividomycin [INN:DCF]; Lividomycinum [INN-Latin]; Lividomycine [INN-French]; Lividomicina [INN-Spanish]; UNII-A606AJ494W; BRN 6763509; CHEBI:71961; Lividomycin A sulfate salt; A606AJ494W Click to Show/Hide
Indication	In total 1 Indication(s) Discovery agent [ICD-11: N.A.] Investigative [1]
Structure
Drug Resistance Disease(s)	*Disease(s) with Resistance Information Validated by in-vivo* Model for This Drug** (1 diseases) Bacterial infection [ICD-11: 1A00-1C4Z] [1]
Target	TERT messenger RNA (TERT mRNA)	TERT_HUMAN	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C29H55N5O18
IsoSMILES	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H](C[C@@H]([C@H](O2)CO)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O[C@@H]5[C@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)N)O)O)N
InChI	1S/C29H55N5O18/c30-3-11-23(51-28-20(43)19(42)17(40)13(5-36)47-28)18(41)15(34)27(45-11)50-24-14(6-37)48-29(21(24)44)52-25-16(39)7(31)1-8(32)22(25)49-26-9(33)2-10(38)12(4-35)46-26/h7-29,35-44H,1-6,30-34H2/t7-,8+,9-,10+,11+,12-,13-,14-,15-,16+,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+/m1/s1
InChIKey	DBLVDAUGBTYDFR-SWMBIRFSSA-N
PubChem CID	72394
ChEBI ID	CHEBI:71961
TTD Drug ID	D07SQW
DrugBank ID	DB04728

Type(s) of Resistant Mechanism of This Drug

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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Bacterial infection [ICD-11: 1A00-1C4Z]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Key Molecule: Aminoglycoside 3'-phosphotransferase (A3AP)			[1]
Molecule Alteration	Expression	Inherence	Molecule Info
Resistant Disease	Streptococcus faecalis infection [ICD-11: 1A00-1C4Z]		Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Escherichia coli strain JM 10		562
	Escherichia coli strain k802		562
	Streptococcus faecnlis strain JHZ-15		1351
Experiment for Molecule Alteration	Chemical sequencing method assay
Experiment for Drug Resistance	Disc sensitivity tests assay
Mechanism Description	Strain BM2182 was examined for aminoglyco- side-modifying activities. That kanamycin B was modified and tobramycin (3'-deoxykanamycin B) was not, indicates that the 3'-hydroxyl group is the site of phosphorylation. That butirosin, lividomycin A, and amikacin were phosphorylated indicates that the enzyme is APH-III.

References

Ref 1	Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III. Gene. 1983 Sep;23(3):331-41. doi: 10.1016/0378-1119(83)90022-7.