Ritonavir (ID: DG00577) Resistance Data of HIV

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: HIV1 Reverse transcriptase (HIV1 RT)				Molecule Info
Resistant Disease	Human immunodeficiency virus infection [ICD-11: 1C62.0]
Molecule Alteration	Alteration Patterns Alteration Types Resistance Mutation Total Point Scores Levels of Drug resistance base on the total point score Ref p.G48T+p.L89M Mutation N.A. Resistance [1]
Resistant Drug	Ritonavir			Drug Info
Experimental Note	Discovered Using In-vivo Testing Model
Experiment for Molecule Alteration	Molecular dynamics simulation assay
Mechanism Description	The decrease in van der Waals interactions of inhibitors with the mutated PR relative to the wild-type (WT) PR mostly drives the drug resistance of mutations toward these four inhibitors. The energy decomposition analysis further indicates that the drug resistance of mutations can be mainly attributed to the change in van der Waals and electrostatic energy of some key residues (around Ala28/Ala28' and Ile50/Ile50'). Our work can give significant guidance to design a new generation of anti-AIDS inhibitors targeting PR in the therapy of patients with HIV-1 infection.

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