Disease Information

General Information of the Disease (ID: DIS00389)

• Name: Liver diseases
• ICD: ICD-11: DB90-DB9Z

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Protirelin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Peptidylprolyl isomerase F (cyclophilin F) (Ppif) [1]

• Resistant Disease: Oxidative stress-related liver diseases [ICD-11: DB90-DB9Z]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Protirelin
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Tshr -/- mice model; Mus musculus
• Experiment for Molecule Alteration: Microarray assay; qRT-PCR; ELISA assay; Western bloting analysis
• Mechanism Description: TSH stimulates hepatic CypD acetylation through the LncRNA-AK044604/SIRT1/SIRT3 signaling pathway, indicating an essential role for TSH in mitochondrial stress in the liver.

Investigative Drug(s) 1 drug(s) in total

Carbon tetrachloride

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: COX2 (COX2) [2]

• Resistant Disease: Liver diseases [ICD-11: DB90-DB9Z]
• Molecule Alteration: .
• Resistant Drug: Carbon tetrachloride
• Experimental Note: Identified from the Human Clinical Data
• In Vivo Model: Male BALB/c nude mice model; Mus musculus
• Mechanism Description: Expression of COX-2 and LncRNA-COX-2 increased with the progression of liver fibrosis. LncRNA-COX-2 may potentially be considered as a novel therapeutic target for liver fibrosis.

References

• Ref 1: Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D AcetylationOxid Med Cell Longev. 2020 Jan 6;2020:1249630. doi: 10.1155/2020/1249630. eCollection 2020.
• Ref 2: Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachlorideMol Med Rep. 2017 Apr;15(4):1507-1512. doi: 10.3892/mmr.2017.6161. Epub 2017 Feb 2.