General Information of the Disease (ID: DIS00381)
Name
Parotid gland cancer
ICD
ICD-11: 2B67
Type(s) of Resistant Mechanism of This Disease
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Clinical Trial Drug(s)
1 drug(s) in total
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Capivasertib
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: RAC-alpha serine/threonine-protein kinase (AKT1) [1]
Sensitive Disease Parotid gland cancer [ICD-11: 2B67.0]
Molecule Alteration Missense mutation
p.E17K (c.49G>A)
Sensitive Drug Capivasertib
Experimental Note Identified from the Human Clinical Data
In Vitro Model Breast .
Mechanism Description The missense mutation p.E17K (c.49G>A) in gene AKT1 cause the sensitivity of Capivasertib by aberration of the drug's therapeutic target
References
Ref 1 Capivasertib Active against AKT1-Mutated CancersCancer Discov. 2019 Jan;9(1):OF7. doi: 10.1158/2159-8290.CD-NB2018-153. Epub 2018 Nov 14.

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