Disease Information
General Information of the Disease (ID: DIS00381)
Name |
Parotid gland cancer
|
---|---|
ICD |
ICD-11: 2B67
|
Type(s) of Resistant Mechanism of This Disease
ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Clinical Trial Drug(s)
1 drug(s) in total
Capivasertib
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Key Molecule: RAC-alpha serine/threonine-protein kinase (AKT1) | [1] | |||
Sensitive Disease | Parotid gland cancer [ICD-11: 2B67.0] | |||
Molecule Alteration | Missense mutation | p.E17K (c.49G>A) |
||
Sensitive Drug | Capivasertib | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Breast | . | ||
Mechanism Description | The missense mutation p.E17K (c.49G>A) in gene AKT1 cause the sensitivity of Capivasertib by aberration of the drug's therapeutic target |
References
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