Disease Information

General Information of the Disease (ID: DIS00349)

• Name: Hyperglycemia
• ICD: ICD-11: MA18

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Mangostin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: H19, imprinted maternally expressed transcript (H19) [1]

• Resistant Disease: Hyperglycemia [ICD-11: MA18.0]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Mangostin
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: HUVEC-12 cells; Endothelium; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: RNA-seq assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: H19 exerted its function via the modulation of H19/miR-140/HE4 in hyperglycemia with alpha-Mangostin.

References

• Ref 1: Downregulation of lncRNA H19 sensitizes melanoma cells to cisplatin by regulating the miR-18b/IGF1 axisAnticancer Drugs. 2020 Jun;31(5):473-482. doi: 10.1097/CAD.0000000000000888.