General Information of the Disease (ID: DIS00302)
Name
Sinusitis
ICD
ICD-11: CA0A
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cefprozil
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Penicillin-binding protein 2B (PBP2B) [1], [2], [3]
Resistant Disease Streptococcus pneumoniae infection [ICD-11: AA80.2]
Molecule Alteration Missense mutation
p.T445A
Resistant Drug Cefprozil
Experimental Note Identified from the Human Clinical Data
In Vitro Model Streptococcus pneumoniae isolates 1313
Experiment for
Molecule Alteration
Genome sequence assay
Experiment for
Drug Resistance
Agar dilution method assay
Mechanism Description MICs for and PBP affinities of the strains correlated with the changes found in the PBP active binding sites.The PBP2b T445-A substitution found in all PISP and PRSP and one PSSP has been found in all low-level Beta-lactam-resistant pneumococci examined.
References
Ref 1 Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45. doi: 10.1128/AAC.00626-06. Epub 2006 Aug 28.
Ref 2 Resistance to Beta-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins. Antibiotics (Basel). 2016 Sep 28;5(4):35. doi: 10.3390/antibiotics5040035.
Ref 3 Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance. J Biol Chem. 2009 Jan 9;284(2):1202-12. doi: 10.1074/jbc.M805761200. Epub 2008 Nov 4.

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