Disease Information

General Information of the Disease (ID: DIS00277)

• Name: Spastic cerebral palsy
• ICD: ICD-11: 8D20

Type(s) of Resistant Mechanism of This Disease

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rocuronium

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Key Molecule: Cytochrome P450 family 3 subfamily A member1 (CYP3A4) [1]

• Resistant Disease: Spastic cerebral palsy [ICD-11: 8D20.1]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Rocuronium
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: Staining and imaging assay
• Mechanism Description: Resistance to neuromuscular blocking agents has been linked to the hepatoxicity of anticonvulsants and the upregulation of drug-metabolizing liver enzymes, especially CYP3A4, which is known to metabolize ROC, Although it was not possible to biopsy liver samples for the present study, elevated CYP3A4 generally correlates with increased circulating alanine transaminase (ALT) and total bilirubin.

References

• Ref 1: Resistance to Neuromuscular Blockade by Rocuronium in Surgical Patients with Spastic Cerebral Palsy .J Pers Med. 2021 Aug 3;11(8):765. doi: 10.3390/jpm11080765. 10.3390/jpm11080765