Disease Information

General Information of the Disease (ID: DIS00228)

• Name: Thrombocytopenia
• ICD: ICD-11: 3B64

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Prednisone

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Resistant Disease: Primary immune thrombocytopenia [ICD-11: 3B64.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Prednisone
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: B-cells; Peripheral blood; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Flow cytometry assay
• Experiment for Drug Resistance: Rhodamine 123 efflux assay
• Mechanism Description: The functional activity and mRNA level of P-gp were significantly higher in glucocorticoids-nonresponsive patients than in glucocorticoids-responsive patients with primary immune thrombocytopenia.

References

• Ref 1: Effects of the multidrug resistance-1 gene on drug resistance in primary immune thrombocytopenia .Autoimmunity. 2016 Nov;49(7):486-495. doi: 10.1080/08916934.2016.1191476. Epub 2016 Jun 3. 10.1080/08916934.2016.1191476