General Information of the Disease (ID: DIS00213)
Name
Germ cell tumor
ICD
ICD-11: 2D12
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cisplatin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: HIC ZBTB transcriptional repressor 1 (HIC1) [1]
Resistant Disease Germ cell tumor [ICD-11: 2D12.Y]
Molecule Alteration Methylation
Up-regulation
Resistant Drug Cisplatin
Experimental Note Identified from the Human Clinical Data
In Vitro Model 833K-E cells Ascites Homo sapiens (Human) CVCL_2292
Experiment for
Molecule Alteration
Western blotting assay
Mechanism Description Promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin.
Key Molecule: Ras association domain-containing protein 1 (RASSF1) [1]
Resistant Disease Germ cell tumor [ICD-11: 2D12.Y]
Molecule Alteration Methylation
Up-regulation
Resistant Drug Cisplatin
Experimental Note Identified from the Human Clinical Data
In Vitro Model 833K-E cells Ascites Homo sapiens (Human) CVCL_2292
Experiment for
Molecule Alteration
Western blotting assay
Mechanism Description Promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin.
References
Ref 1 Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors .Mol Cancer. 2004 May 18;3:16. doi: 10.1186/1476-4598-3-16. 10.1186/1476-4598-3-16

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