Disease Information
General Information of the Disease (ID: DIS00213)
Name |
Germ cell tumor
|
---|---|
ICD |
ICD-11: 2D12
|
Resistance Map |
Type(s) of Resistant Mechanism of This Disease
EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Cisplatin
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Epigenetic Alteration of DNA, RNA or Protein (EADR) | ||||
Key Molecule: HIC ZBTB transcriptional repressor 1 (HIC1) | [1] | |||
Resistant Disease | Germ cell tumor [ICD-11: 2D12.Y] | |||
Molecule Alteration | Methylation | Up-regulation |
||
Resistant Drug | Cisplatin | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | 833K-E cells | Ascites | Homo sapiens (Human) | CVCL_2292 |
Experiment for Molecule Alteration |
Western blotting assay | |||
Mechanism Description | Promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin. | |||
Key Molecule: Ras association domain-containing protein 1 (RASSF1) | [1] | |||
Resistant Disease | Germ cell tumor [ICD-11: 2D12.Y] | |||
Molecule Alteration | Methylation | Up-regulation |
||
Resistant Drug | Cisplatin | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | 833K-E cells | Ascites | Homo sapiens (Human) | CVCL_2292 |
Experiment for Molecule Alteration |
Western blotting assay | |||
Mechanism Description | Promoter hypermethylation of RASSF1A and HIC1 genes play a role in resistance of GCT, while the transcriptional inactivation of MGMT by epigenetic alterations confer exquisite sensitivity to cisplatin. |
References
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