Disease Information

General Information of the Disease (ID: DIS00156)

• Name: Whooping cough
• ICD: ICD-11: 1C12

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Erythromycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: 23S rRNA (cytidine-2'-O)-methyltransferase TlyA (TLYA) [1]

• Resistant Disease: Bordetella pertussis infection [ICD-11: 1C12.0]
• Molecule Alteration: Missense mutation; p.A2047G
• Resistant Drug: Erythromycin
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Bordetella pertussis isolate; 1952
• Experiment for Molecule Alteration: Whole genome sequencing assay
• Experiment for Drug Resistance: Disk diffusion assay
• Mechanism Description: All of the strains of B. pertussis resistant to erythromycin in our center had the A2047G mutation of the 23S rRNA gene.

References

• Ref 1: Analysis of antibiotic sensitivity and resistance genes of Bordetella pertussis in Chinese children .Medicine (Baltimore). 2021 Jan 15;100(2):e24090. doi: 10.1097/MD.0000000000024090. 10.1097/MD.0000000000024090