General Information of the Disease (ID: DIS00138)
Name
Preterm delivery
ICD
ICD-11: JB00
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Ciprofloxacin XR
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: DNA topoisomerase 4 subunit A (PARC) [1], [2]
Resistant Disease Preterm delivery with lung infection in neonates [ICD-11: JB00.0]
Molecule Alteration Missense mutation
p.S83W
Resistant Drug Ciprofloxacin XR
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli k-12 JM109 83333
Ureaplasma parvum serovar 3 isolates 38504
Ureaplasma parvum serovar 6 isolates 95660
Ureaplasma urealyticum isolates 2130
Ureaplasma parvum isolates 38504
Experiment for
Molecule Alteration
Whole genome sequence assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description Quinolones are used for treating urogenital infections and interact in bacteria with the type II topoisomerases DNA gyrase and topoisomerase IV, both of which are composed of two A and two B subunits; these subunits are encoded by the gyrA and gyrB genes for DNA gyrase and parC and parE genes for topoisomerase IV.Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L.
Key Molecule: DNA topoisomerase 4 subunit A (PARC) [1], [2]
Resistant Disease Preterm delivery with lung infection in neonates [ICD-11: JB00.0]
Molecule Alteration Missense mutation
p.S83P
Resistant Drug Ciprofloxacin XR
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli k-12 JM109 83333
Ureaplasma parvum serovar 3 isolates 38504
Ureaplasma parvum serovar 6 isolates 95660
Ureaplasma urealyticum isolates 2130
Ureaplasma parvum isolates 38504
Experiment for
Molecule Alteration
Whole genome sequence assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description Quinolones are used for treating urogenital infections and interact in bacteria with the type II topoisomerases DNA gyrase and topoisomerase IV, both of which are composed of two A and two B subunits; these subunits are encoded by the gyrA and gyrB genes for DNA gyrase and parC and parE genes for topoisomerase IV.Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L.
Key Molecule: DNA topoisomerase 4 subunit A (PARC) [1], [2]
Resistant Disease Preterm delivery with lung infection in neonates [ICD-11: JB00.0]
Molecule Alteration Missense mutation
ParC p.S83L+GyrB p.P462S
Resistant Drug Ciprofloxacin XR
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli k-12 JM109 83333
Ureaplasma parvum serovar 3 isolates 38504
Ureaplasma parvum serovar 6 isolates 95660
Ureaplasma urealyticum isolates 2130
Ureaplasma parvum isolates 38504
Experiment for
Molecule Alteration
Whole genome sequence assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description Quinolones are used for treating urogenital infections and interact in bacteria with the type II topoisomerases DNA gyrase and topoisomerase IV, both of which are composed of two A and two B subunits; these subunits are encoded by the gyrA and gyrB genes for DNA gyrase and parC and parE genes for topoisomerase IV.Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L.
References
Ref 1 In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan. Antimicrob Agents Chemother. 2015 Apr;59(4):2358-64. doi: 10.1128/AAC.04262-14. Epub 2015 Feb 2.
Ref 2 Analysis of mutations in DNA gyrase and topoisomerase IV of Ureaplasma urealyticum and Ureaplasma parvum serovars resistant to fluoroquinolones. Infect Genet Evol. 2017 Jan;47:64-67. doi: 10.1016/j.meegid.2016.11.019. Epub 2016 Nov 21.

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