Disease Information

General Information of the Disease (ID: DIS00011)

Type(s) of Resistant Mechanism of This Disease

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

Click to Show/Hide the Full List of Drugs

Ciprofloxacin XR

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Key Molecule: DNA gyrase subunit A (GYRA)			[1]
Resistant Disease	Typhoid fever [ICD-11: 1A07.0]
Molecule Alteration	Missense mutation	p.S83F	Molecule Info
Resistant Drug	Ciprofloxacin XR		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Salmonella enterica subsp. enterica serovar Typhi isolates		90370
Experiment for Molecule Alteration	PCR-RFLP
Experiment for Drug Resistance	MIC assay
Mechanism Description	The targets of fluoroquinolones are the two enzymes, DNA gyrase and topoisomerase IV, whose subunits are encoded respectively by gyrA and gyrB and the parC and parE genes.The alteration caused by single point mutations within the QRDR of the DNA gyrase subunit gyrA gene leads to quinolone resistance.

Nalidixic acid

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Key Molecule: DNA topoisomerase 4 subunit A (PARC)			[1]
Resistant Disease	Typhoid fever [ICD-11: 1A07.0]
Molecule Alteration	Missense mutation	p.W106G	Molecule Info
Resistant Drug	Nalidixic acid		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Salmonella enterica subsp. enterica serovar Typhi isolates		90370
Experiment for Molecule Alteration	PCR-RFLP
Experiment for Drug Resistance	MIC assay
Mechanism Description	The targets of fluoroquinolones are the two enzymes, DNA gyrase and topoisomerase IV, whose subunits are encoded respectively by gyrA and gyrB and the parC and parE genes.The alteration caused by single point mutations within the QRDR of the DNA gyrase subunit gyrA gene leads to quinolone resistance.

References

Ref 1	GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital. J Clin Diagn Res. 2016 Jul;10(7):DC14-8. doi: 10.7860/JCDR/2016/17677.8153. Epub 2016 Jul 1.