Disease Information

General Information of the Disease (ID: DIS00002)

• Name: Inflammation
• ICD: ICD-11: 1A00-CA43

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Dexamethasone

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: ATP-binding cassette sub-family B5 (ABCB5) [1]

• Sensitive Disease: Inflammation [ICD-11: 1A00-CA43]
• Molecule Alteration: Expression; Down-regulation
• Sensitive Drug: Dexamethasone
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: Adult male CF-1 abcb1a(+/+) mice moodel; Crl:CF1- abcb1a(-/-) mice model; Mus musculus
• Mechanism Description: The multidrug resistance transporter, P-glycoprotein (P-gp), contributes to highly lipophilic molecules penetrating the brain from the blood at a much lower rate than expected, and has numerous substrates, inhibitors and modulators. Dexamethasone was shown to be transported in vitro by abcb1b and showed little to no transport by abcb1a; however, in vivo tissue accumulation of dexamethasone was increased in abcb1a-deficient mice compared to abcb1a-deficien.

Investigative Drug(s) 1 drug(s) in total

Picric acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA (MIRT2) [2]

• Resistant Disease: TNF-alpha-triggered inflammation [ICD-11: 3B81.Z]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Picric acid
• Experimental Note: Identified from the Human Clinical Data
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Overexpression assay; Knockdown assay; ELISA assay; Mimic assay
• Mechanism Description: Long non-coding RNA Mirt2 prevents TNF-alpha-triggered inflammation via the repression of microRNA-101.

References

• Ref 1: Changes in the brain accumulation of glucocorticoids in abcb1a-deficient CF-1 mice. J Neuroendocrinol. 2012 Nov;24(11):1440-6. doi: 10.1111/j.1365-2826.2012.02353.x.
• Ref 2: Long non-coding RNA Mirt2 prevents TNF-Alpha-triggered inflammation via the repression of microRNA-101Int Immunopharmacol. 2019 Nov;76:105878. doi: 10.1016/j.intimp.2019.105878. Epub 2019 Sep 9.