Molecule Information

General Information of the Molecule (ID: Mol02226)

• Name: Long non-protein coding RNA (UC.333) ,Mus musculus
• Synonyms: UC.333
• Molecule Type: LncRNA
• Gene Name: UC.333

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Insulin recombinant

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Type 2 diabetes mellitus [1]

• Resistant Disease: Type 2 diabetes mellitus [ICD-11: 5A11.0]
• Resistant Drug: Insulin recombinant
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HepG2 cells; Liver; Homo sapiens (Human); CVCL_0027
• In Vivo Model: Male db/db mice;C57BL/6 mice model; Mus musculus
• Experiment for Molecule Alteration: Microarray assay; Western bloting analysis; Fluorescence in situ hybridization; Overexpression assay; Knockdown assay
• Mechanism Description: UC.333 improves IR by binding to miR-223; thus, uc.333 may be a useful target for the treatment and prevention of IR.

References

• Ref 1: Ultraconserved element uc.333 increases insulin sensitivity by binding to miR-223Aging (Albany NY). 2020 Apr 17;12(8):6667-6679. doi: 10.18632/aging.103020. Epub 2020 Apr 17.