Molecule Information

General Information of the Molecule (ID: Mol02213)

• Name: Long non-protein coding RNA (RP11-166P13.3) ,Homo sapiens
• Synonyms: RP11-166P13.3
• Molecule Type: LncRNA
• Gene Name: RP11-166P13.3

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Estradiol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Ovarian cancer [1]

• Resistant Disease: Ovarian cancer [ICD-11: 2C73.0]
• Resistant Drug: Estradiol
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SkOV3 cells; Ovary; Homo sapiens (Human); CVCL_0532
• In Vitro Model: UWB1.289 cells; Ovary; Homo sapiens (Human); CVCL_B079
• In Vitro Model: OVCAR3 cells; Ovary; Homo sapiens (Human); CVCL_0465
• In Vitro Model: CAOV3 cells; Ovary; Homo sapiens (Human); CVCL_0201
• In Vivo Model: Male nude mice xenograft model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; RNA pull down assay; FISH assay; RIP experiments assay; Knockdown assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: Long Non-Coding RNA LINC00511 Mediates the Effects of ESR1 on Proliferation and Invasion of Ovarian Cancer Through miR-424-5p and miR-370-5p.

References

• Ref 1: Long Non-Coding RNA LINC00511 Mediates the Effects of ESR1 on Proliferation and Invasion of Ovarian Cancer Through miR-424-5p and miR-370-5pCancer Manag Res. 2019 Dec 27;11:10807-10819. doi: 10.2147/CMAR.S232140. eCollection 2019.