Molecule Information

General Information of the Molecule (ID: Mol02212)

Name	Long non-protein coding RNA (HNF4A-AS1) ,Homo sapiens
Synonyms	HNF4A-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	HNF4A-AS1
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Acetaminophen

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Cholangiocarcinoma				[1]
Resistant Disease	Cholangiocarcinoma [ICD-11: 2C12.0]			Disease Info
Resistant Drug	Acetaminophen			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepaRG cells	Liver	Homo sapiens (Human)	CVCL_9720
Experiment for Molecule Alteration	Knockdown assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Altogether, our study suggests that HNF1alpha-AS1 and HNF4alpha-AS1 affected AILI mainly through alterations of P450-mediated APAP biotransformation in HepaRG cells, indicating an important role of the LncRNAs in AILI.

References

Ref 1	Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1Alpha Antisense RNA 1 and Hepatocyte Nuclear Factor 4Alpha Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG CellsMol Pharmacol. 2020 Apr;97(4):278-286. doi: 10.1124/mol.119.118778. Epub 2020 Feb 6.

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