Molecule Information

General Information of the Molecule (ID: Mol02209)

• Name: Long non-protein coding RNA (RAMS11) ,Homo sapiens
• Synonyms: RAMS11
• Molecule Type: LncRNA
• Gene Name: RAMS11

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Clinical Trial Drug(s) 1 drug(s) in total

Afeletecan

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Colorectal cancer [1]

• Resistant Disease: Colorectal cancer [ICD-11: 2B91.1]
• Resistant Drug: Afeletecan
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: SW480 cells; Colon; Homo sapiens (Human); CVCL_0546
• In Vitro Model: CCD18-Co cells; Colon; Homo sapiens (Human); CVCL_2379
• In Vivo Model: NOD/SCID mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay; Overexpression assay; qRT-PCR; Western bloting analysis; RNA-seq; RIP experiments assay; ChIP assay; RNA pull down assay
• Experiment for Drug Resistance: Soft agar assay
• Mechanism Description: Overall, recent clinical trials using topoisomerase inhibitors coupled with our findings of RAMS11-dependent regulation of TOP2alpha supports the potential use of RAMS11 as a biomarker and therapeutic target for mCRC.

References

• Ref 1: Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progressionNat Commun. 2020 May 1;11(1):2156. doi: 10.1038/s41467-020-15547-8.